ChEMBL ligand: CHEMBL56337 (Aldonil, Aldorin, Epalrestat, Kinedak, Tanglin)
Aldehyde reductase in Human [ChEMBL: CHEMBL2246] [UniProtKB: P14550] Aldehyde reductase in Pig [ChEMBL: CHEMBL4049] [UniProtKB: P50578] Aldehyde reductase in Rat [ChEMBL: CHEMBL3871] [UniProtKB: P51635] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] Aldose reductase in Bovine [ChEMBL: CHEMBL3081] [UniProtKB: P16116] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Sorbitol dehydrogenase in Human [ChEMBL: CHEMBL2275] [UniProtKB: Q00796] There should be some charts here, you may need to enable JavaScript!
CYP4A11 in Human [GtoPdb: 1341] [UniProtKB: Q02928] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of human recombinant AKR1A1 expressed in Escherichia coli BL21 cells using D-glucuronate as substrate by spectrophotometry	B	5.59	pIC50	2600	nM	IC50	Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435]
Aldehyde reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4049] [UniProtKB: P50578]
ChEMBL	Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase values	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635]
ChEMBL	In vitro inhibitory activity against rat kidney aldehyde reductase(ALR).	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1997) 40: 684-694 [PMID:9057855]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of recombinant N-His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometry	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435]
ChEMBL	Inhibition of AKR1B10 (unknown origin) pretreated with 0.42M DMSO followed by compound treatment by DMSO-perturbation assay	B	7.41	pIC50	39.3	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of AKR1B10 (unknown origin) pretreated with 0.25M DMSO followed by compound treatment by DMSO-perturbation assay	B	7.45	pIC50	35.2	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis	B	4.9	pIC50	12500	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5630-5633 [PMID:20805028]
ChEMBL	Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured after 30 mins at 2 mins interval by spectrophotometry relative to control	B	6.21	pIC50	620	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-perturbation assay	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPH	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of human recombinant aldose reductase expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in NADPH oxidation using L-idose as substrate	B	6.99	pIC50	102	nM	IC50	Bioorg Med Chem Lett (2018) 28: 3712-3720 [PMID:30342956]
ChEMBL	Inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometry	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2012) 20: 356-367 [PMID:22104435]
ChEMBL	Inhibition of aldose reductase (unknown origin)	B	7.03	pIC50	93.9	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4482-4487 [PMID:28802633]
ChEMBL	Inhibition of recombinant human ALR2 assessed as reduction in NADPH oxidation measured for 5 mins in presence of D,L-glyceraldehyde by spectrophotometric method	B	7.07	pIC50	85	nM	IC50	Eur J Med Chem (2017) 125: 965-974 [PMID:27769036]
ChEMBL	Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measured for 3 mins by spectrophotometric analysis	B	7.18	pIC50	66.5	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4870-4874 [PMID:27666634]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction	B	7.68	pIC50	21	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibitory activity against aldose reductase enzyme	B	8	pIC50	10	nM	IC50	J Med Chem (2003) 46: 417-426 [PMID:12540241]
Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116]
ChEMBL	Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysis	B	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2011) 21: 200-203 [PMID:21129963]
ChEMBL	Inhibition of bovine lens ALR2	B	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2011) 46: 2797-2806 [PMID:21531055]
ChEMBL	Inhibition of bovine aldose reductase assessed as oxidation of NADPH	B	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2014) 81: 1-14 [PMID:24819954]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of Wistar rat kidney ALR1 assessed as reduction in NADPH oxidation using sodium D-glucuronate and NADPH as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric analysis	B	5.3	pIC50	5000	nM	IC50	Eur J Med Chem (2021) 215: 113269-113269 [PMID:33588177]
ChEMBL	Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for 30 mins at 2 mins interval by spectrophotometry relative to control	B	5.49	pIC50	3210	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of Wistar rat kidney ALR1 using sodium D-glucuronate as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method	B	5.65	pIC50	2257	nM	IC50	Bioorg Med Chem (2019) 27: 1658-1669 [PMID:30858026]
ChEMBL	In vitro inhibitory activity against rat kidney Aldehyde reductase	B	5.82	pIC50	1500	nM	IC50	J Med Chem (1996) 39: 1924-1927 [PMID:8627616]
ChEMBL	Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis	B	6.07	pIC50	860	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis relative to control	B	6.28	pIC50	530	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic analysis relative to control	B	6.29	pIC50	510	nM	IC50	Eur J Med Chem (2019) 168: 154-175 [PMID:30818176]
ChEMBL	Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometry	B	6.6	pIC50	250	nM	IC50	J Med Chem (2015) 58: 2649-2657 [PMID:25695864]
ChEMBL	Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition measured after 4 mins by spectrophotometric analysis	B	6.64	pIC50	227	nM	IC50	Bioorg Med Chem (2017) 25: 6353-6360 [PMID:29074349]
ChEMBL	Inhibition of Sprague-Dawley albino rat ALR2 assessed as enzyme-mediated oxidation of NADPH using D,L-glyceraldehyde as substrate by spectrophotometric analysis	B	6.77	pIC50	170	nM	IC50	Eur J Med Chem (2012) 51: 216-226 [PMID:22436396]
ChEMBL	Inhibition of Sprague-Dawley albino rat lens ALR2 by spectrophotometry	B	6.77	pIC50	170	nM	IC50	J Med Chem (2012) 55: 10523-10531 [PMID:23134227]
ChEMBL	Inhibition of ALR2 from rat lens using D,L-glyceraldehyde as substrate measured as absorption of NADPH for 4 mins by UV/vis spectrophotmetry	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2880-2885 [PMID:27156769]
ChEMBL	Inhibition of Wistar rat lens ALR2 using D,L-glyceraldehyde as substrate after 10 mins by UV/VIS double spectrophotometric analysis	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2011) 19: 7262-7269 [PMID:22036211]
ChEMBL	Inhibition of Wistar rat eye lens aldose reductase-2 using D-L glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometric analysis	B	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2014) 80: 383-392 [PMID:24793885]
ChEMBL	Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric analysis	B	6.97	pIC50	108.1	nM	IC50	Eur J Med Chem (2021) 215: 113269-113269 [PMID:33588177]
ChEMBL	Inhibition of rat kidney NADPH-dependent aldose reductase assessed as DL-glyceraldehyde conversion to glycerol preincubated for 20 mins followed by NADPH addition measured after 5 mins by UV-Visible spectrophotometric analysis	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2014) 71: 53-66 [PMID:24275248]
ChEMBL	Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate assessed as decrease in NADPH oxidation preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometer	B	7.07	pIC50	86	nM	IC50	Bioorg Med Chem Lett (2017) 27: 887-892 [PMID:28109789]
ChEMBL	Inhibition of Wistar rat ALR2 using D,L-glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate addition measured for 4 mins by spectrophotometric analysis	B	7.07	pIC50	85.68	nM	IC50	Bioorg Med Chem Lett (2015) 25: 3924-3927 [PMID:26227780]
ChEMBL	Inhibition of Wistar rat lenses ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured after 5 mins by spectrophotometry	B	7.08	pIC50	84	nM	IC50	J Med Chem (2015) 58: 1254-1267 [PMID:25602762]
ChEMBL	Inhibition of AKR1B1 in rat lenses	B	7.09	pIC50	81	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127101-127101 [PMID:32192796]
ChEMBL	Inhibition of rat lens aldose reductase using DL-glyceraldehyde as substrate after 30 mins by fluorescence microplate reader analysis	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem (2012) 20: 832-840 [PMID:22209731]
ChEMBL	Inhibition of aldose reductase in rat lens homogenates by fluorophotometer	B	7.14	pIC50	72	nM	IC50	J Nat Prod (2002) 65: 1151-1155 [PMID:12193020]
ChEMBL	Inhibition of rat lens aldose reductase	B	7.15	pIC50	70	nM	IC50	J Nat Prod (2008) 71: 713-715 [PMID:18298080]
ChEMBL	Inhibition of Sprague-Dawley rat lens aldose reductase	B	7.17	pIC50	67	nM	IC50	J Nat Prod (2012) 75: 267-270 [PMID:22264115]
ChEMBL	Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins at 30 degC followed by substrate addition and measured after 4 mins in presence of NADPH	B	7.35	pIC50	45	nM	IC50	Bioorg Med Chem (2020) 28: 115699-115699 [PMID:33069078]
ChEMBL	DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde)	B	7.49	pIC50	32	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of Wistar rat lens ALR2 using L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition and measured for 4 mins by spectrophotometric method	B	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2019) 27: 1658-1669 [PMID:30858026]
ChEMBL	Inhibitory activity against purified rat lens aldose reductase (RLAR)	B	7.64	pIC50	23	nM	IC50	J Med Chem (1994) 37: 787-792 [PMID:8145228]
ChEMBL	In vitro inhibitory activity against partially purified rat lens Aldose reductase at a dose of 5e-7M	B	7.68	pIC50	21	nM	IC50	J Med Chem (1996) 39: 1924-1927 [PMID:8627616]
ChEMBL	Inhibitory activity against rat lens aldose reductase(AR).	B	7.68	pIC50	21	nM	IC50	J Med Chem (1997) 40: 684-694 [PMID:9057855]
ChEMBL	Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate	B	7.89	pIC50	13	nM	IC50	J Med Chem (1991) 34: 1011-1018 [PMID:1900532]
ChEMBL	Inhibition of crude aldose reductase of rat lens	B	8	pIC50	10	nM	IC50	J Med Chem (1986) 29: 2024-2028 [PMID:3093680]
Sorbitol dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2275] [UniProtKB: Q00796]
ChEMBL	Inhibition sorbitol dehydrogenase by spectrophotometric analysis	B	4.17	pIC50	67700	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5630-5633 [PMID:20805028]
CYP4A11 in Human [GtoPdb: 1341] [UniProtKB: Q02928]
GtoPdb	-	-	5.74	pIC50	1820	nM	IC50	J Pharmacol Exp Ther (2018) 366: 446-457 [PMID:29976573]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]