CPN-267

Ligand id: 10380

Name: CPN-267

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
IUPAC Name
deamino-2-thien-2-yl-glycyl-L-tryptophyl-alpha-methyl-L-tryptophyl-L-arginyl-L-prolyl-L-arginyl-L-asparaginamide
Synonyms
analogue 7b [PMID: 28548497] | C-terminal core peptide derivative of neuromedin U, bearing (α-Me)Trp2 | NMUR1 agonist C7b
Comments
CPN-267 is a Neuromedin U receptor 1 (NMUR1) selective agonist [1]. It is a hexapeptide based on the C-terminal core peptide of human neuromedin U. α-methylation of the Trp residue at position 3 improves the peptide's agonistic activity and its selectivity for NMUR1.
The HELM annotation for the hexapaptide is: PEPTIDE1{[*C(=O)Cc1cccs1 |$_R2;;;;;;;;$|].W.[*C(=O)[C@](C)(Cc1c[nH]c2c1cccc2)N* |$_R2;;;;;;;;;;;;;;;;_R1$|].R.P.R.N.[am]}$$$$, and the IUPAC condensed name is deamino-Gly(thien-2-yl)-Trp-aMeTrp-Arg-Pro-Arg-Asn-NH2 (both from PubChem).
Database Links
PubChem CID 132585191
Search Google for chemical match using the InChIKey HIFICJJBGBSZMZ-YWIJTBFMSA-N
Search Google for chemicals with the same backbone HIFICJJBGBSZMZ
Search UniChem for chemical match using the InChIKey HIFICJJBGBSZMZ-YWIJTBFMSA-N
Search UniChem for chemicals with the same backbone HIFICJJBGBSZMZ