doxapram [Ligand Id: 7169] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1754 (Docatone, Doxapram) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 7 | pIC50 | 100 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| K2P3.1/Potassium channel subfamily K member 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4294] [GtoPdb: 515] [UniProtKB: O54912] | ||||||||
| ChEMBL | Inhibition of rat TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| K2P9.1/Potassium channel subfamily K member 9 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295] [GtoPdb: 520] [UniProtKB: Q9ES08] | ||||||||
| ChEMBL | Inhibition of rat TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assay | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| ChEMBL | Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assay | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
