doxapram [Ligand Id: 7169] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1754 (Docatone, Doxapram) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 7 | pIC50 | 100 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| K2P3.1/Potassium channel subfamily K member 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4294] [GtoPdb: 515] [UniProtKB: O54912] | ||||||||
| ChEMBL | Inhibition of rat TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay | B | 6.39 | pIC50 | 410 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| K2P9.1/Potassium channel subfamily K member 9 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295] [GtoPdb: 520] [UniProtKB: Q9ES08] | ||||||||
| ChEMBL | Inhibition of rat TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assay | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| ChEMBL | Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assay | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
