RS67506 [Ligand Id: 3230] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL83899 (RS-67506)
  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • 5-HT4 receptor in Rat [GtoPdb: 9] [UniProtKB: Q62758]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosae F 8.6 pEC50 2.51 nM EC50 Bioorg. Med. Chem. Lett. (1994) 4: 2477-2480
5-HT4 receptor in Rat [GtoPdb: 9] [UniProtKB: Q62758]
GtoPdb - - 8.8 pEC50 1.58 nM EC50 FASEB J. (1996) 10: 1398-407 [PMID:8903510]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]