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ChEMBL ligand: CHEMBL1561 (BAY M 1099, BAY-M-1099, Diastabol, Glyset, Miglitol, NSC-758702) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
GtoPdb | - | - | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718] |
alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9] | ||||||||
ChEMBL | Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis | B | 6.34 | pKi | 460 | nM | Ki | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of rat intestinal brush border membrane maltase | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of rat intestinal maltase using moltose as substrate | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of Wistar rat small intestine maltase after 30 mins | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
Alpha-glucosidase in Aspergillus niger (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3435] [UniProtKB: P56526] | ||||||||
ChEMBL | Inhibition of Aspergillus niger alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.24 | pIC50 | 57140 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258] |
Alpha-mannosidase in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3392945] [UniProtKB: C0HJB3] | ||||||||
ChEMBL | Inhibition of Canavalia ensiformis alpha-mannosidase using p-nitrophenyl-alpha-D-mannopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.12 | pIC50 | 75880 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258] |
Beta-galactosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3482] [UniProtKB: Q58D55] | ||||||||
ChEMBL | Inhibition of bovine liver beta-galactosidase using 10 mM p-nitrophenyl-beta-D-galactopyranoside as substrate | B | 4 | pKi | 100000 | nM | Ki | J Med Chem (2015) 58: 7820-7832 [PMID:26375725] |
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062] | ||||||||
ChEMBL | Inhibition of human lysosomal beta-glucosidase | B | 4.08 | pIC50 | 84000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574] | ||||||||
ChEMBL | Inhibition of rabbit muscle amylo-1,6-glucosidase | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848] | ||||||||
ChEMBL | Inhibition of lactase by HPLC | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
ChEMBL | Inhibition of lysosomal alpha-glucosidase by HPLC | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
ChEMBL | Inhibition of maltase in human Caco-2 cell model system after 2 hrs | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of human lysosomal alpha-glucosidase | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
GtoPdb | - | - | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718] |
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451] | ||||||||
GtoPdb | Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay | - | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem (2010) 18: 7794-8 [PMID:20970346] |
ChEMBL | Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay | B | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem (2010) 18: 7794-7798 [PMID:20970346] |
ChEMBL | Inhibition of maltase by HPLC | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
ChEMBL | Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase method | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem Lett (2021) 33: 127751-127751 [PMID:33347966] |
maltase-glucoamylase in Mouse [GtoPdb: 2627] | ||||||||
GtoPdb | - | - | 6.68 | pKi | 211 | nM | Ki | Bioorg Med Chem (2011) 19: 3929-34 [PMID:21669536] |
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410] | ||||||||
ChEMBL | Inhibition of sucrase by HPLC | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739] | ||||||||
ChEMBL | Inhibition of rat intestinal isomaltase using isomaltase as substrate | B | 4.41 | pIC50 | 39000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 4.41 | pIC50 | 39000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of Wistar rat small intestine isomaltase after 30 mins | B | 4.41 | pIC50 | 39000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
ChEMBL | Inhibition of rat small intestinal isomaltase using isomaltose as substrate incubated for 30 mins by glucose-oxidase method | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of rat intestinal brush border membrane isomaltase | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of rat intestinal sucrase using sucrose as substrate | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat small intestine sucrase after 30 mins | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
ChEMBL | Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method | B | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of rat intestinal brush border membrane sucrase | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]