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ChEMBL ligand: CHEMBL1561 (BAY M 1099, BAY-M-1099, Diastabol, Glyset, Miglitol, NSC-758702) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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alpha glucosidase in Human [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
GtoPdb | - | - | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718] |
alpha glucosidase/Acidic alpha-glucosidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3513] [GtoPdb: 2611] [UniProtKB: Q6P7A9] | ||||||||
ChEMBL | Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis | B | 6.34 | pKi | 460 | nM | Ki | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of rat intestinal brush border membrane maltase | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of rat intestinal maltase using moltose as substrate | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of Wistar rat small intestine maltase after 30 mins | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
Alpha-glucosidase in Aspergillus niger (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3435] [UniProtKB: P56526] | ||||||||
ChEMBL | Inhibition of Aspergillus niger alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.24 | pIC50 | 57140 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258] |
Alpha-mannosidase in Canavalia ensiformis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3392945] [UniProtKB: C0HJB3] | ||||||||
ChEMBL | Inhibition of Canavalia ensiformis alpha-mannosidase using p-nitrophenyl-alpha-D-mannopyranoside as substrate preincubated for 1 hr followed by substrate addition measured after 10 mins by spectrophotometric method | B | 4.12 | pIC50 | 75880 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5291-5295 [PMID:29074258] |
Beta-galactosidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3482] [UniProtKB: Q58D55] | ||||||||
ChEMBL | Inhibition of bovine liver beta-galactosidase using 10 mM p-nitrophenyl-beta-D-galactopyranoside as substrate | B | 4 | pKi | 100000 | nM | Ki | J Med Chem (2015) 58: 7820-7832 [PMID:26375725] |
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062] | ||||||||
ChEMBL | Inhibition of human lysosomal beta-glucosidase | B | 4.08 | pIC50 | 84000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
Glycogen debranching enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5273] [UniProtKB: P35574] | ||||||||
ChEMBL | Inhibition of rabbit muscle amylo-1,6-glucosidase | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848] | ||||||||
ChEMBL | Inhibition of lactase by HPLC | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
alpha glucosidase/Lysosomal alpha-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2608] [GtoPdb: 2611] [UniProtKB: P10253] | ||||||||
ChEMBL | Inhibition of lysosomal alpha-glucosidase by HPLC | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
ChEMBL | Inhibition of maltase in human Caco-2 cell model system after 2 hrs | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of human lysosomal alpha-glucosidase | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
GtoPdb | - | - | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-6 [PMID:18595718] |
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451] | ||||||||
GtoPdb | Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay | - | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem (2010) 18: 7794-8 [PMID:20970346] |
ChEMBL | Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay | B | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem (2010) 18: 7794-7798 [PMID:20970346] |
ChEMBL | Inhibition of maltase by HPLC | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
ChEMBL | Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase method | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase method | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem Lett (2021) 33: 127751-127751 [PMID:33347966] |
maltase-glucoamylase in Mouse [GtoPdb: 2627] | ||||||||
GtoPdb | - | - | 6.68 | pKi | 211 | nM | Ki | Bioorg Med Chem (2011) 19: 3929-34 [PMID:21669536] |
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410] | ||||||||
ChEMBL | Inhibition of sucrase by HPLC | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2010) 53: 689-698 [PMID:20000679] |
Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739] | ||||||||
ChEMBL | Inhibition of rat intestinal isomaltase using isomaltase as substrate | B | 4.41 | pIC50 | 39000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 4.41 | pIC50 | 39000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of Wistar rat small intestine isomaltase after 30 mins | B | 4.41 | pIC50 | 39000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
ChEMBL | Inhibition of rat small intestinal isomaltase using isomaltose as substrate incubated for 30 mins by glucose-oxidase method | B | 5.34 | pIC50 | 4600 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of rat intestinal brush border membrane isomaltase | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL | Inhibition of rat intestinal sucrase using sucrose as substrate | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2012) 55: 10347-10362 [PMID:23106358] |
ChEMBL | Inhibition of Wistar rat small intestine sucrase after 30 mins | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 738-741 [PMID:21185187] |
ChEMBL | Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometry | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3298-3301 [PMID:24973028] |
ChEMBL | Inhibition of rat small intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase method | B | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem (2016) 24: 3705-3715 [PMID:27325449] |
ChEMBL | Inhibition of rat intestinal brush border membrane sucrase | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2008) 16: 7330-7336 [PMID:18595718] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]