IBC 293 [Ligand Id: 1597] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL381638
  • HCA3 receptor/HM74 nicotinic acid GPCR in Human [ChEMBL: CHEMBL4421] [GtoPdb: 313] [UniProtKB: P49019]
  • This target only has 0 pki data point
  • 0
1 CHEMBL381638_lig_chart_1 HM74 nicotinic acid GPCR Human
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  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
  • This target only has 0 pki data point
  • 0
2 CHEMBL381638_lig_chart_2 Hydroxycarboxylic acid receptor 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA3 receptor/HM74 nicotinic acid GPCR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4421] [GtoPdb: 313] [UniProtKB: P49019]
ChEMBL Agonistic activity at GPR109b by cAMP whole cell assay F 6.4 pEC50 398.11 nM EC50 J. Med. Chem. (2006) 49: 1227-1230 [PMID:16480258]
GtoPdb - - 6.4 pEC50 398 nM EC50 J Med Chem (2006) 49: 1227-30 [PMID:16480258]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production F 6.4 pEC50 400 nM EC50 J. Med. Chem. (2008) 51: 7653-7662 [PMID:18983141]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]