zanamivir [Ligand Id: 12307] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL222813 (GG-167, GG167, GR-121167, GR 121167X, GR-121167X, Relenza, Zanamivir) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] | ||||||||
| ChEMBL | Inhibition of Influenza A virus A/California/04/2009 (H1N1) Neuraminidase H274Y mutant using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2022) 65: 11550-11573 [PMID:35939763] |
| Neuraminidase in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2051] [UniProtKB: P03468] | ||||||||
| ChEMBL | Inhibition of Influenza A virus A/PuertoRico/8/1934 (H1N1) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2023) 252: 115275-115275 [PMID:36931117] |
| ChEMBL | Inhibition of Influenza A virus A/PR/8/1934 (H1N1) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | B | 7.81 | pIC50 | 15.39 | nM | IC50 | J Med Chem (2022) 65: 11550-11573 [PMID:35939763] |
| ChEMBL | Inhibition of Influenza A virus (A/goose/Guangdong/SH7/2013(H5N1)) Neuraminidase N1 preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 mins by fluorescence method | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2020) 187: 111940-111940 [PMID:31835169] |
| ChEMBL | Compound was tested for its inhibitory activity against A/Victoria/3/75 (N2) sialidases. | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Inhibition of Influenza A virus (A/PuertoRico/8/1934(H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.27 | pIC50 | 5.31 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus A/PR/8/1934 (H1N1) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader analysis | B | 8.29 | pIC50 | 5.16 | nM | IC50 | J Med Chem (2021) 64: 17992-18009 [PMID:34735766] |
| ChEMBL | Inhibition of influenza A sialidase (neuraminidase) | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 2931-2936 |
| ChEMBL | Compound was tested for inhibitory concentration against Influenza sialidase type A | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1998) 41: 798-807 [PMID:9526556] |
| ChEMBL | Inhibition of influenza sialidase was determined by measuring the ability to inhibit the hydrolysis of MUN by A/Aichi virus grown in hen eggs | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1805-1808 |
| ChEMBL | inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza A virus | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (2000) 43: 3482-3486 [PMID:11000002] |
| ChEMBL | Inhibition of Influenza A virus A/Duck/313/4/78(H5N3) sialidase preincubated for 15 mins followed by MUNA substrate addition measured after 15 mins by fluorescence assay | B | 8.65 | pIC50 | 2.23 | nM | IC50 | Bioorg Med Chem (2018) 26: 17-24 [PMID:29198893] |
| ChEMBL | Compound was tested for its inhibitory activity against A/USSR/90/77 (N1) sialidases. | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Inhibitory activity against influenza A sialidase (Aichi) | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 669-673 [PMID:11266166] |
| ChEMBL | Inhibitory activity against influenza A neuraminidase | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2001) 44: 4379-4392 [PMID:11728184] |
| ChEMBL | Compound was tested for its inhibitory activity against A/Aichi/2/68 (N2) sialidases. | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Inhibitory activity against influenza A virus sialidase | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2239-2242 |
| ChEMBL | Inhibition of human Influenza A virus A/PR/8/34(H1N1) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.81 | pIC50 | 1.56 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
| ChEMBL | Compound was tested for its inhibitory activity against A/PR/8/34 (N1) sialidases. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Inhibition of Influenza A virus A/PR/8/34(H1N1) sialidase preincubated for 15 mins followed by MUNA substrate addition measured after 15 mins by fluorescence assay | B | 9.28 | pIC50 | 0.52 | nM | IC50 | Bioorg Med Chem (2018) 26: 17-24 [PMID:29198893] |
| ChEMBL | Inhibitory activity was determined against Neuraminidase A from influenza virus A/Tokyo/3/67 | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2001) 44: 1192-1201 [PMID:11312919] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667683] [UniProtKB: Q6Q793] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by by Michaelis-Menten equation analysis | B | 9.3 | pKi | 0.5 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/reassortant/NIBRG-14(Viet Nam/1194/2004 x Puerto Rico/8/1934)(H5N1)) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay | B | 8.32 | pIC50 | 4.8 | nM | IC50 | J Med Chem (2012) 55: 8657-8670 [PMID:23009169] |
| ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase by fluorometric assay | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| Neuraminidase in Influenza B virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295840] [UniProtKB: Q3S340] | ||||||||
| ChEMBL | Inhibition of Influenza B virus (B/Perth/211/2001) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 6.78 | pIC50 | 167.4 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza B virus (B/Perth/211/2001) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667685] [UniProtKB: Q2LFS1] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 9.4 | pKi | 0.4 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2005 (H5N1) neuraminidase H274Y mutant using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis | B | 7.38 | pIC50 | 42 | nM | IC50 | Eur J Med Chem (2023) 252: 115275-115275 [PMID:36931117] |
| ChEMBL | Inhibition of Influenza A virus A/California/04/2009 (H5N1) neuraminidase H274Y mutant using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis | B | 7.46 | pIC50 | 35 | nM | IC50 | Eur J Med Chem (2023) 252: 115275-115275 [PMID:36931117] |
| ChEMBL | Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) neuraminidase H274Y mutant using 4-MU-NANA as substrate preincubated for 5 mins followed by substrate addition and measured after 30 to 60 mins by fluorescence assay | B | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2021) 212: 113097-113097 [PMID:33385836] |
| ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2005 (H5N1) Neuraminidase H274Y mutant using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method | B | 8.02 | pIC50 | 9.6 | nM | IC50 | J Med Chem (2021) 64: 17992-18009 [PMID:34735766] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)) neuraminidase by fluorometric assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| Neuraminidase in Influenza A virus (strain A/Udorn/307/1972 H3N2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046263] [UniProtKB: P0DOF9] | ||||||||
| ChEMBL | Binding affinity to zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells measured up to 400 sec by surface plasmon resonance analysis | B | 8.33 | pKd | 4.7 | nM | Kd | J Med Chem (2016) 59: 6303-6312 [PMID:27341624] |
| ChEMBL | Inhibition of Influenza A virus A/Udorn/1972(H3N2) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay | B | 7.64 | pIC50 | 22.9 | nM | IC50 | J Med Chem (2012) 55: 8657-8670 [PMID:23009169] |
| ChEMBL | Inhibition of zanamivir/oseltamivir resistant recombinant Influenza A virus (A/Moscow/10/99(H3N2)) Neuraminidase N2 E119V/I222L double mutant expressed in baculovirus infected insect cells using 4-MU-NANA as substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | B | 7.81 | pIC50 | 15.4 | nM | IC50 | J Med Chem (2016) 59: 6303-6312 [PMID:27341624] |
| Neuraminidase in Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287610] [UniProtKB: P03470] | ||||||||
| ChEMBL | Inhibition of wild type Influenza A virus A/WSN/1933(H1N1) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2012) 55: 8657-8670 [PMID:23009169] |
| ChEMBL | Inhibition of Influenza A virus A/WSN/1933(H1N1)) neuraminidase in the presence of 2'-(4-methyl-umbelliferyl)-alphaD-N-acetylneuraminic acid substrate after 10 mins by fluorometric assay | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2012) 55: 8493-8501 [PMID:22963087] |
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus A/WSN/1933/H275Y(H1N1) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2012) 55: 8657-8670 [PMID:23009169] |
| ChEMBL | Inhibition of Influenza A virus (A/WSN/1933(H1N1)) wild type neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured for 15 mins by fluorescence assay | B | 9 | pIC50 | 1 | nM | IC50 | Eur J Med Chem (2018) 154: 314-323 [PMID:29843102] |
| ChEMBL | Competitive inhibition of MDCK infected Influenza A virus A/WSN/33(H1N1) neuraminidase using MU-NANA as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by spectrofluorometric method | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Eur J Med Chem (2016) 123: 397-406 [PMID:27487569] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232678] [UniProtKB: Q194T1] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/RI/5+/1957(H2N2)) recombinant neuraminidase using MUNANA as substrate after 30 mins | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem (2014) 22: 2236-2243 [PMID:24613627] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 9.52 | pKi | 0.3 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus neuraminidase | B | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem (2010) 18: 4074-4084 [PMID:20452227] |
| ChEMBL | Inhibition of influenza A nuraminidase N1 | B | 9.8 | pKi | 0.16 | nM | Ki | J Med Chem (2010) 53: 7377-7391 [PMID:20873795] |
| ChEMBL | Inhibition of influenza A/N1/PR/8/34 neuraminidase | B | 10.22 | pKi | 0.06 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993] |
| ChEMBL | Inhibition of Influenza A virus A/Brisbane/10/2007(H3N2) recombinant neuraminidase E119A mutant transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 4.08 | pIC50 | >83000 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase A119A mutant isolated from virus-infected BALB/c mouse by fluorometric assay | B | 5.78 | pIC50 | 1659 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/NWS/G70C(H1N9)) neuraminidase E119G mutant activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 6.09 | pIC50 | 815.9 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/NWS/G70C(H1N9)) neuraminidase E119G mutant activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 6.17 | pIC50 | 678.4 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of influenza virus neuraminidase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2008) 51: 3878-3894 [PMID:18558668] |
| ChEMBL | Inhibition of Influenza A virus A/Brisbane/10/2007(H3N2) recombinant neuraminidase R292K mutant transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus H5N1 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
| ChEMBL | Inhibition of Influenza A virus H3N2 neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
| ChEMBL | Inhibition of Influenza A virus (A/Babol/36/2005(H3N2)) neuraminidase E119V mutant activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 7.47 | pIC50 | 33.55 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Guangdong/674/2014(H5N6)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 7.64 | pIC50 | 22.8 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/Anhui/1/2013(H7N9)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 7.75 | pIC50 | 17.61 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of influenza A virus neuraminidase | B | 7.81 | pIC50 | 15.36 | nM | IC50 | Eur J Med Chem (2023) 255: 115410-115410 [PMID:37120995] |
| ChEMBL | Inhibition of Influenza A virus (A/Wisconsin/67/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 7.85 | pIC50 | 14.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus A/Taiwan/3446/2002(H3N2) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay | B | 7.86 | pIC50 | 13.8 | nM | IC50 | J Med Chem (2012) 55: 8657-8670 [PMID:23009169] |
| ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) neuraminidase N294S mutant after 30 mins by fluorescence analysis | B | 7.87 | pIC50 | 13.5 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Chicken/Hebei/LZF/2014(H5N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 7.89 | pIC50 | 13.01 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus H5N1 Neuraminidase N1 H274Y mutant preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 mins by fluorescence method | B | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2020) 187: 111940-111940 [PMID:31835169] |
| ChEMBL | Inhibition of Influenza A virus (A/Indonesia/5/2005(H5N1)) X-31 recombinant neuraminidase using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate after 1 hr by fluorescence assay | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2012) 54: 764-770 [PMID:22795831] |
| ChEMBL | Inhibition of Influenza A virus (A/California/07/09 (H1N1)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Vietnam/08/2004 (H5N1)) clade 1 neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/Indonesia/5/2005(H5N1)) neuraminidase infected in chick embryo using MUNANA as substrate after 1 hr by spectrophotometric analysis | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2013) 56: 671-684 [PMID:23330908] |
| ChEMBL | Inhibition of Influenza A virus (A/Aichi/75/2008(H3N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 7.94 | pIC50 | 11.51 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/seal/Massachusetts/1/1980(H7N7)) neuraminidase after 30 mins by fluorescence analysis | B | 7.94 | pIC50 | 11.5 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) neuraminidase R292K mutant after 30 mins by fluorescence analysis | B | 7.95 | pIC50 | 11.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Wyoming/03/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 7.97 | pIC50 | 10.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus A/California/07/2009 (H1N1) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
| ChEMBL | Inhibition of Influenza A virus (A/goose/Guangdong/SH7/2013(H5N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.01 | pIC50 | 9.81 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/Kitakyushu/159/1993(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.03 | pIC50 | 9.3 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/china/415/2013(H9N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.04 | pIC50 | 9.15 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/Aichi/102/2008(H3N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.04 | pIC50 | 9.08 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Wellington/1/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.06 | pIC50 | 8.74 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/England/1/1956(H11N6)) neuraminidase after 30 mins by fluorescence analysis | B | 8.07 | pIC50 | 8.57 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/IMS22A-954/2003(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.08 | pIC50 | 8.29 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/California/07/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.09 | pIC50 | 8.21 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Kawasaki/MS31A-1030/2002(H3N2)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.11 | pIC50 | 7.82 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Mississippi/03/01 (H1N1)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 8.11 | pIC50 | 7.8 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/Yokohama/IMS9A-2029/2003(H3N2)) neuraminidase E119V mutant after 30 mins by fluorescence analysis | B | 8.11 | pIC50 | 7.71 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/1/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.12 | pIC50 | 7.58 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/goose/Jiangsu/1306/2014(H5N8)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.13 | pIC50 | 7.39 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/New York/55/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.13 | pIC50 | 7.35 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Aichi/2/1968(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.13 | pIC50 | 7.33 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Saitama/80/2003(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.15 | pIC50 | 7.16 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Babol/36/2005(H3N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.17 | pIC50 | 6.82 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/2/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.19 | pIC50 | 6.45 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Saitama/07/2006(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.22 | pIC50 | 6.04 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Mississippi/03/01 (H1N1)) neuraminidase H274Y mutant using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus A/Shanghai/01/2014(H7N9) recombinant wild type neuraminidase transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Shiga/8/2004(H4N6)) neuraminidase N6 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.23 | pIC50 | 5.86 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/swine/Shepparton/6/2009 (H1N1)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 8.24 | pIC50 | 5.8 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/turkey/Ontario/6,118/1968(H8N4)) neuraminidase after 30 mins by fluorescence analysis | B | 8.25 | pIC50 | 5.58 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/28/2006(H3N8)) neuraminidase N8 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.26 | pIC50 | 5.53 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus A/duck/Tsukuba/441/05(H11N9) neuraminidase N9 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.26 | pIC50 | 5.44 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Hiroshima/52/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.29 | pIC50 | 5.11 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of influenza A virus neuraminidase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 7137-7141 [PMID:22001088] |
| ChEMBL | Inhibition of Influenza A virus (A/Osaka/56/2004(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.32 | pIC50 | 4.84 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Shiga/5/2002(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.32 | pIC50 | 4.82 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/California/04/2009(H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.36 | pIC50 | 4.32 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus A/Brisbane/10/2007(H3N2) recombinant wild type neuraminidase transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus A/WSN/1933(H1N1) neuraminidase | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2010) 18: 4074-4084 [PMID:20452227] |
| ChEMBL | Inhibition of human influenza A virus A/DK/HK/313/4/78(H5N3) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.4 | pIC50 | 3.97 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
| ChEMBL | Inhibition of Influenza A virus (A/Singapore/1/1957(H2N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.44 | pIC50 | 3.66 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Hokkaido/84/2002(H5N3)) neuraminidase after 30 mins by fluorescence analysis | B | 8.44 | pIC50 | 3.65 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.44 | pIC50 | 3.62 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/700/2007(H7N7)) neuraminidase N7 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.45 | pIC50 | 3.51 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Tokushima/1/2005(H3N2)) neuraminidase after 30 mins by fluorescence analysis | B | 8.47 | pIC50 | 3.42 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of recombinant Influenza A virus H3N2 neuraminidase | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3256-3260 [PMID:26077494] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Memphis/546/1974(H11N9)) neuraminidase after 30 mins by fluorescence analysis | B | 8.48 | pIC50 | 3.31 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 11)(H1N1)) neuraminidase H274Y mutant after 30 mins by fluorescence analysis | B | 8.52 | pIC50 | 3.05 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/R(duck/Mongolia/54/01-duck/Mongolia/47/01)(H5H1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.52 | pIC50 | 2.99 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of influenza A/WSN/1933 (H1N1) virus neuraminidase N1 using MUNANA substrate by fluorimetric assay | B | 8.57 | pIC50 | 2.7 | nM | IC50 | Bioorg Med Chem (2011) 19: 4796-4802 [PMID:21778065] |
| ChEMBL | Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 1)(H1N1)) wild type neuraminidase after 30 mins by fluorescence analysis | B | 8.57 | pIC50 | 2.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/32/1989(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.59 | pIC50 | 2.55 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus A/Kitakyushu/10/06(H1N1) neuraminidase N1 H274Y mutant activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Vietnam/08/2004 (H5N1)) clade 1 neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of influenza A virus A/Vietnam/1194/2004 H5N1 neuraminidase using NA-STAR substrate after 15 mins incubation at room temperature by fluorescent assay | B | 8.6 | pIC50 | 2.5 | nM | IC50 | J Med Chem (2009) 52: 4903-4910 [PMID:19522501] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/28/2005(H6N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.62 | pIC50 | 2.42 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of influenza A virus A/WSN/1933 H1N1 neuraminidase using NA-STAR substrate after 15 mins incubation at room temperature by fluorescent assay | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2009) 52: 4903-4910 [PMID:19522501] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/394/2005(H5N3)) neuraminidase N3 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.63 | pIC50 | 2.33 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Mississippi/03/01 (H1N1)) neuraminidase H274Y mutant using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.66 | pIC50 | 2.2 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus A/duck/Chiba/13/06(H12N5) neuraminidase N5 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.66 | pIC50 | 2.17 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/New Caledonia/20/1999(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.69 | pIC50 | 2.05 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/WSN/1933(H1N1)) neuraminidase H275Y mutant using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured for 15 mins by fluorescence assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2018) 154: 314-323 [PMID:29843102] |
| ChEMBL | Inhibition of Influenza A virus (A/Mississippi/03/01 (H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.72 | pIC50 | 1.9 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of recombinant Influenza A virus H5N1 neuraminidase | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3256-3260 [PMID:26077494] |
| ChEMBL | Inhibition of Influenza A virus A/WSN/1933(H1N1) recombinant neuraminidase H275Y mutant transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 8.72 | pIC50 | 1.9 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Alberta/60/1976(H12N5)) neuraminidase after 30 mins by fluorescence analysis | B | 8.74 | pIC50 | 1.83 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Narita/1/2009(H1N1)) neuraminidase N1 V149I mutant activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.74 | pIC50 | 1.8 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus A/Vietnam/1194/2004(H5N1) recombinant neuraminidase H275Y mutant transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/3/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.77 | pIC50 | 1.68 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/mallard/Hokkaido/24/2009(H5N1)) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.78 | pIC50 | 1.66 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Shiga/1/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.79 | pIC50 | 1.63 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/California/04/2009(H1N1)) neuraminidase N1 V149I mutant activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of recombinant Influenza A virus H1N1 neuraminidase | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3256-3260 [PMID:26077494] |
| ChEMBL | Inhibition of Influenza A virus (A/Sydney/5/1997(H3N2)) neuraminidase infected in chick embryo using MUNANA as substrate after 1 hr by spectrophotometric analysis | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2013) 56: 671-684 [PMID:23330908] |
| ChEMBL | Inhibition of Influenza A virus (A/Sydney/5/97(H3N2)) recombinant neuraminidase using 2'-(4- methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate after 1 hr by fluorescence assay | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Eur J Med Chem (2012) 54: 764-770 [PMID:22795831] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) neuraminidase after 30 mins by fluorescence analysis | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/swine/Shepparton/6/2009 (H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/Saitama/78/2003(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.86 | pIC50 | 1.38 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus A/Yamaguchi/20/06(H1N1) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 8.92 | pIC50 | 1.19 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.92 | pIC50 | 1.19 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Aichi/193/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.93 | pIC50 | 1.17 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/57/2002(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 8.94 | pIC50 | 1.14 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/California/07/09 (H1N1)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of influenza virus neuraminidase | B | 9 | pIC50 | 1 | nM | IC50 | Medchemcomm (2014) 5: 1483-1488 |
| ChEMBL | Inhibition of Influenza A virus A/Hong Kong/8/1968 (H3N2) neuraminidase using MUNANA as substrate preincubated for 30 mins measured after 2 hrs | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 636-643 [PMID:24374271] |
| ChEMBL | Inhibition of influenza A virus (A/Guangdong/376/2001(H1N1)) neuraminidase infected in chick embryo using MUNANA as substrate after 1 hr by spectrophotometric analysis | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2013) 56: 671-684 [PMID:23330908] |
| ChEMBL | Inhibition of Influenza A virus (A/Yamagata/83/2006(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 9.06 | pIC50 | 0.88 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase by fluorometric assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/Okinawa/42/2004(H1N1)) neuraminidase after 30 mins by fluorescence analysis | B | 9.12 | pIC50 | 0.75 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 186-192 [PMID:18955520] |
| ChEMBL | Inhibition of Influenza A virus (A/whooper swan/Mongolia/1/2009(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus A/Vietnam/1194/2004(H5N1) recombinant wild type neuraminidase transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Hong Kong/68(H3N2) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 9.18 | pIC50 | 0.66 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus A/WSN/1933(H1N1) recombinant wild type neuraminidase transfected in HEK293 cells using MUNANA as substrate assessed as release of 4-methylumbelliferone preincubated for 10 mins followed by substrate addition measured after 15 mins by fluorometric assay | B | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2016) 59: 5297-5310 [PMID:27167096] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/20/2007(H8N4)) neuraminidase N4 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 9.24 | pIC50 | 0.58 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Sachsen/6/02(H3N2) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 9.31 | pIC50 | 0.49 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Tsukuba/67/2005(H1N1)) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | B | 9.33 | pIC50 | 0.47 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Berlin/10/04(H3N2) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of neuraminidase H274Y mutant in Oseltamivir-resistant Influenza A virus A/Berlin/55/08(H1N1) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 9.54 | pIC50 | 0.29 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Rheinland-Pfalz/3911/03(H3N2) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/HH/1580/09(H1N1) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 10.3 | pIC50 | 0.05 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Jena/5555/09(H1N1) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 10.4 | pIC50 | 0.04 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| ChEMBL | Inhibition of neuraminidase in Influenza A virus A/Jena/5258/2009(H1N1) using Na-star as substrate preincubated for 10 to 30 mins followed by substrate addition measured after 10 to 30 mins by chemiluminescence-based assay | B | 10.52 | pIC50 | 0.03 | nM | IC50 | J Med Chem (2014) 57: 759-769 [PMID:24422530] |
| Neuraminidase in Influenza A virus (A/Memphis/1/1971(H3N2)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6015] [UniProtKB: P03471] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/Fukui/45/04(H3N2)) neuraminidase E119V mutant activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 7.28 | pIC50 | 51.9 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus A/Babo1/36/2005 (H3N2) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis | B | 7.37 | pIC50 | 43 | nM | IC50 | Eur J Med Chem (2023) 252: 115275-115275 [PMID:36931117] |
| ChEMBL | Inhibition of Influenza A virus (A/Fukui/45/04(H3N2)) neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 7.49 | pIC50 | 32.4 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/Chicken/Hebei/LZF/2014(H5N2)) Neuraminidase N2 preincubated for 10 mins followed by MUNANA substrate addition and measured after 40 mins by fluorescence method | B | 7.68 | pIC50 | 21 | nM | IC50 | Eur J Med Chem (2020) 187: 111940-111940 [PMID:31835169] |
| ChEMBL | Inhibition of Influenza A virus (A/Fukui/45/04(H3N2)) neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.42 | pIC50 | 3.8 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus (A/Fukui/45/04(H3N2)) neuraminidase E119V mutant activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus A/Memphis/1/71(H3N2) sialidase preincubated for 15 mins followed by MUNA substrate addition measured after 15 mins by fluorescence assay | B | 8.76 | pIC50 | 1.73 | nM | IC50 | Bioorg Med Chem (2018) 26: 17-24 [PMID:29198893] |
| Neuraminidase in Influenza A virus (strain A/Duck/Ukraine/1/1963 H3N8) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295592] [UniProtKB: Q07599] | ||||||||
| ChEMBL | Inhibition of Influenza A virus A/goose/Jiangsu/1306/2014(H5N8) neuraminidase N8 using fluorogenic MUNANA as substrate preincubated for 10 mins followed by substrate addition measured after 40 to 60 mins by fluorescence-based assay | B | 8.13 | pIC50 | 7.43 | nM | IC50 | J Med Chem (2018) 61: 9976-9999 [PMID:30365885] |
| Neuraminidase in Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295612] [UniProtKB: Q6XV28] | ||||||||
| ChEMBL | Inhibition of Influenza A virus A/duck/Guangdong/674/2014(H5N6) neuraminidase N6 using fluorogenic MUNANA as substrate preincubated for 10 mins followed by substrate addition measured after 40 to 60 mins by fluorescence-based assay | B | 7.64 | pIC50 | 22.8 | nM | IC50 | J Med Chem (2018) 61: 9976-9999 [PMID:30365885] |
| Neuraminidase in Influenza A virus (A/Aichi/2/1968(H3N2)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287607] [UniProtKB: Q75VQ4] | ||||||||
| ChEMBL | Inhibition of human influenza A virus A/Aichi/2/1968(H3N2) neuraminidase by fluorometric method using 4MU-NeuAc substrate | B | 8.58 | pIC50 | 2.66 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667684] [UniProtKB: A5Z252] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 9 | pKi | 1 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Bangli/BBVD-563/2007(H5N1)) clade 2 neuraminidase activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 7.95 | pIC50 | 11.2 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza A virus A/Anhui/1/2005(H5N1) neuraminidase N1 H274Y mutant using fluorogenic MUNANA as substrate preincubated for 10 mins followed by substrate addition measured after 40 to 60 mins by fluorescence-based assay | B | 8.12 | pIC50 | 7.67 | nM | IC50 | J Med Chem (2018) 61: 9976-9999 [PMID:30365885] |
| ChEMBL | Inhibition of Influenza A virus (A/Turkey/651242/2006(H5N1)) neuraminidase by fluorometric assay | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/chicken/Bangli/BBVD-563/2007(H5N1)) clade 2 neuraminidase activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| Neuraminidase in Influenza B virus (strain B/Lee/1940) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3377] [UniProtKB: P03474] | ||||||||
| ChEMBL | Inhibition of influenza B/Memphis/3/89 neuraminidase | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 1692-1695 [PMID:18242993] |
| ChEMBL | Inhibition of Influenza B virus (B/Perth/211/2001) neuraminidase D197E mutant activity using 4-MUNANA as substrate measured every min for 60 mins by fluorescence assay | B | 6.36 | pIC50 | 433.8 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibition of Influenza B virus (B/Perth/211/2001) neuraminidase D197E mutant activity using 4-MUNANA as substrate preincubated for 60 mins followed by substrate addition measured every min for 60 mins by fluorescence assay | B | 6.59 | pIC50 | 257.5 | nM | IC50 | J Med Chem (2018) 61: 1921-1933 [PMID:29397718] |
| ChEMBL | Inhibitory activity against influenza B virus sialidase | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2239-2242 |
| ChEMBL | Inhibitory activity against influenza B neuraminidase | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2001) 44: 4379-4392 [PMID:11728184] |
| ChEMBL | Compound was tested for its inhibitory activity against B/Lee/40 sialidases. | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Inhibition of influenza B sialidase (neuraminidase) | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 2931-2936 |
| ChEMBL | Inhibitory activity against influenza B sialidase (Victoria) | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 669-673 [PMID:11266166] |
| ChEMBL | Inhibition of influenza sialidase was determined by measuring the ability to inhibit the hydrolysis of MUN by B Victoria virus grown in hen eggs | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1805-1808 |
| ChEMBL | Compound was tested for inhibitory concentration against Influenza sialidase type B | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (1998) 41: 798-807 [PMID:9526556] |
| ChEMBL | Compound was tested for its inhibitory activity against B/Beijing/1/87 (N2) sialidases. | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | Compound was tested for its inhibitory activity against B/Victoria/102/85 (N2) sialidases. | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1998) 41: 787-797 [PMID:9526555] |
| ChEMBL | inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza B virus. | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2000) 43: 3482-3486 [PMID:11000002] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667686] [UniProtKB: C4LRQ6] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by Michaelis-Menten equation analysis | B | 9.3 | pKi | 0.5 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/Anhui/1/2005(H5N1)) neuraminidase H274Y mutant activity using 4-MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured after 40 to 60 mins by chemiluminescence assay | B | 8.17 | pIC50 | 6.71 | nM | IC50 | J Med Chem (2018) 61: 6379-6397 [PMID:29965752] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase by fluorometric assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| ChEMBL | Inhibition of Influenza A virus (A/duck/Laos/25/2006(H5N1)) neuraminidase isolated from virus-infected BALB/c mouse by fluorometric assay | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 3088-3096 [PMID:19349520] |
| neuraminidase 2/Sialidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3200] [GtoPdb: 3258] [UniProtKB: Q9Y3R4] | ||||||||
| ChEMBL | Inhibition of human neuraminidase 2 | B | 4.77 | pKi | 17000 | nM | Ki | J Med Chem (2010) 53: 2998-3002 [PMID:20222714] |
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | B | 5.24 | pKi | 5700 | nM | Ki | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | B | 5.24 | pKi | 5700 | nM | Ki | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | B | 5.24 | pKi | 5700 | nM | Ki | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| ChEMBL | Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | B | 4.79 | pIC50 | 16400 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
| ChEMBL | Inhibition of human NEU2 using 4MU-NeuAc as substrate after 15 to 30 mins by fluorimetric analysis | B | 4.8 | pIC50 | 16000 | nM | IC50 | ACS Med Chem Lett (2013) 4: 532-537 [PMID:24900705] |
| ChEMBL | Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis | B | 4.81 | pIC50 | 15330 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | B | 5.11 | pIC50 | 7800 | nM | IC50 | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| ChEMBL | Inhibition of human NEU2 | B | 5.11 | pIC50 | 7800 | nM | IC50 | J Med Chem (2022) 65: 3002-3025 [PMID:35170942] |
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | B | 5.11 | pIC50 | 7800 | nM | IC50 | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | B | 5.11 | pIC50 | 7800 | nM | IC50 | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-3GalbetapNP as substrate incubated for 30 mins | B | 5.28 | pIC50 | 5300 | nM | IC50 | J Med Chem (2022) 65: 3002-3025 [PMID:35170942] |
| ChEMBL | Inhibition of human recombinant NEU2 expressed in Escherichia coli using Neu5Acalpha2-3GalbetapNP substrate | B | 5.28 | pIC50 | 5300 | nM | IC50 | Medchemcomm (2014) 5: 1067-1074 |
| ChEMBL | Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-6GalbetapNP as substrate incubated for 30 mins | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Med Chem (2022) 65: 3002-3025 [PMID:35170942] |
| Sialidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3046] [UniProtKB: Q9UQ49] | ||||||||
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | B | 6.21 | pKi | 620 | nM | Ki | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | B | 6.21 | pKi | 620 | nM | Ki | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | B | 6.21 | pKi | 620 | nM | Ki | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| ChEMBL | Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis | B | 5.09 | pIC50 | 8170 | nM | IC50 | J Med Chem (2016) 59: 4563-4577 [PMID:27095056] |
| ChEMBL | Inhibition of human neuraminidase 3 assessed as inhibition of GM3 hydrolysis | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7529-7533 [PMID:21036040] |
| ChEMBL | Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | B | 5.17 | pIC50 | 6800 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 3484-3491 [PMID:18694948] |
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | B | 5.4 | pIC50 | 4000 | nM | IC50 | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| Sialidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4174] [UniProtKB: Q8WWR8] | ||||||||
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | B | 4.59 | pKi | 26000 | nM | Ki | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | B | 4.59 | pKi | 26000 | nM | Ki | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured every 30 secs for 30 mins by fluorescence based assay | B | 4.59 | pKi | 26000 | nM | Ki | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| ChEMBL | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | B | 4.33 | pIC50 | 47000 | nM | IC50 | J Med Chem (2018) 61: 1990-2008 [PMID:29425031] |
| ChEMBL | Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | B | 4.33 | pIC50 | 47000 | nM | IC50 | Bioorg Med Chem (2018) 26: 5349-5358 [PMID:29903413] |
| ChEMBL | Inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | B | 4.33 | pIC50 | 47000 | nM | IC50 | WO-2018213933-A1. Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase (2018) |
| ChEMBL | Inhibition of human NEU4 | B | 4.33 | pIC50 | 47000 | nM | IC50 | J Med Chem (2022) 65: 3002-3025 [PMID:35170942] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
