nTzDpa [Ligand Id: 2699] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL370152 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Inhibitory concentration against human peroxisome proliferator activated receptor alpha in SPA assay | B | 4.82 | pIC50 | >15000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay | B | 7.54 | pKd | 29 | nM | Kd | J Med Chem (2013) 56: 1535-1543 [PMID:23286787] |
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Mol Endocrinol (2003) 17: 662-76 [PMID:12554792] |
| ChEMBL | Inhibitory concentration against human peroxisome proliferator activated receptor gamma in SPA assay | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
| ChEMBL | Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay | B | 7.24 | pEC50 | 57 | nM | EC50 | J Med Chem (2015) 58: 5381-5394 [PMID:25734377] |
| ChEMBL | Effective agonist concentration for human PPAR gamma Gal4 construct in transactivation assay | F | 7.26 | pEC50 | 55 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
