nTzDpa [Ligand Id: 2699] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL370152 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Inhibitory concentration against human peroxisome proliferator activated receptor alpha in SPA assay | B | 4.82 | pIC50 | >15000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay | B | 7.54 | pKd | 29 | nM | Kd | J Med Chem (2013) 56: 1535-1543 [PMID:23286787] |
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Mol Endocrinol (2003) 17: 662-76 [PMID:12554792] |
| ChEMBL | Inhibitory concentration against human peroxisome proliferator activated receptor gamma in SPA assay | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
| ChEMBL | Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay | B | 7.24 | pEC50 | 57 | nM | EC50 | J Med Chem (2015) 58: 5381-5394 [PMID:25734377] |
| ChEMBL | Effective agonist concentration for human PPAR gamma Gal4 construct in transactivation assay | F | 7.26 | pEC50 | 55 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 5035-5038 [PMID:16153845] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
