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ChEMBL ligand: CHEMBL82293 (Cetyl acid, Cetylic acid, FEMA NO. 2832, IMEX C 1498, KORTACID 1698, LOXIOL EP 278, N-hexadecanoic acid, NSC-5030, Palmitate, Palmitic acid, Prifac-2960, Pristerene-4934) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method | B | 4.99 | pIC50 | 10150 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607] |
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
ChEMBL | Binding affinity against Adipocyte lipid binding protein | B | 4.08 | pKd | 83000 | nM | Kd | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | Displacement of 1,8-ANS from aFABP by fluorescence based-assay | B | 6.47 | pKi | 336 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
ChEMBL | In vitro inhibitory concentration against adipocyte fatty acid binding protein(A-FABP) | B | 6.03 | pIC50 | 930 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
ChEMBL | Inhibition of FABP4 (unknown origin) by fluorescence polarization assay | B | 6.03 | pIC50 | 930 | nM | IC50 | Eur J Med Chem (2017) 138: 854-873 [PMID:28738306] |
fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469] | ||||||||
ChEMBL | Binding affinity to human kFABP | B | 6.1 | pKd | 802 | nM | Kd | J Med Chem (2006) 49: 5013-5017 [PMID:16884313] |
ChEMBL | Displacement of 1,8-ANS from eFABP by fluorescence based-assay | B | 6.1 | pKi | 802 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
ChEMBL | In vitro inhibitory concentration against epithelial fatty acid binding protein(E-FABP) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
ChEMBL | Inhibition of FABP5 (unknown origin) by fluorescence polarization assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2017) 138: 854-873 [PMID:28738306] |
fatty acid binding protein 2/Fatty acid binding protein intestinal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104] | ||||||||
ChEMBL | Binding affinity against Fatty acid-binding protein | B | 5.43 | pKd | -5.43 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
ChEMBL | In vitro inhibitory concentration against intestinal fatty acid binding protein(I-FABP) | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
fatty acid binding protein 3/Fatty acid binding protein muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3344] [GtoPdb: 2533] [UniProtKB: P05413] | ||||||||
ChEMBL | In vitro inhibitory concentration against heart and muscle fatty acid binding protein(H-FABP) | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
ChEMBL | Inhibition of FABP3 (unknown origin) by fluorescence polarization assay | B | 5.59 | pIC50 | 2600 | nM | IC50 | Eur J Med Chem (2017) 138: 854-873 [PMID:28738306] |
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255] | ||||||||
ChEMBL | Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay | F | 8.01 | pEC50 | 9.8 | nM | EC50 | US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (2018) |
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
ChEMBL | Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay | B | 5.82 | pIC50 | 1500 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
ChEMBL | Agonist activity at recombinant human PPARalpha LBD (168 to 468 residues) expressed in African green monkey COS-1 cells incubated for 18 hrs by luciferase reporter gene assay | B | 4.46 | pEC50 | 35000 | nM | EC50 | Eur J Med Chem (2018) 155: 736-753 [PMID:29940464] |
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
ChEMBL | Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay | B | 5.13 | pIC50 | 7400 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
ChEMBL | Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay | B | 4.52 | pIC50 | 30000 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method | B | 5.06 | pIC50 | 8800 | nM | IC50 | J Nat Prod (2020) 83: 1598-1610 [PMID:32255628] |
TLR2/Toll-like receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4163] [GtoPdb: 1752] [UniProtKB: O60603] | ||||||||
ChEMBL | Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells | F | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2006) 49: 1754-1765 [PMID:16509590] |
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842] | ||||||||
GtoPdb | - | - | 5.3 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11303-11 [PMID:12496284]; Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875]; Nature (2003) 422: 173-6 [PMID:12629551] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]