palmitic acid [Ligand Id: 1055] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL82293 (Palmitic acid)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
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  • fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
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  • fatty acid binding protein 5/Fatty acid binding protein epidermal in Human [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469]
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  • fatty acid binding protein 2/Fatty acid binding protein intestinal in Human [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104]
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  • fatty acid binding protein 3/Fatty acid binding protein muscle in Human [ChEMBL: CHEMBL3344] [GtoPdb: 2533] [UniProtKB: P05413]
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  • Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
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  • Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
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  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
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  • TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
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  • FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method B 4.99 pIC50 10150 nM IC50 Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607]
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
ChEMBL Binding affinity against Adipocyte lipid binding protein B 4.08 pKd 83000 nM Kd J. Med. Chem. (2002) 45: 2469-2483 [PMID:12036355]
ChEMBL Displacement of 1,8-ANS from aFABP by fluorescence based-assay B 6.47 pKi 336 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 3511-3515 [PMID:17502136]
ChEMBL In vitro inhibitory concentration against adipocyte fatty acid binding protein(A-FABP) B 6.03 pIC50 930 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4445-4448 [PMID:15357969]
fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469]
ChEMBL Binding affinity to human kFABP B 6.1 pKd 802 nM Kd J. Med. Chem. (2006) 49: 5013-5017 [PMID:16884313]
ChEMBL Displacement of 1,8-ANS from eFABP by fluorescence based-assay B 6.1 pKi 802 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 3511-3515 [PMID:17502136]
ChEMBL In vitro inhibitory concentration against epithelial fatty acid binding protein(E-FABP) B 5.92 pIC50 1200 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4445-4448 [PMID:15357969]
fatty acid binding protein 2/Fatty acid binding protein intestinal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104]
ChEMBL Binding affinity against Fatty acid-binding protein B 5.43 pKd -5.43 - Log Kd J. Med. Chem. (2002) 45: 2770-2780 [PMID:12061879]
ChEMBL In vitro inhibitory concentration against intestinal fatty acid binding protein(I-FABP) B 5.77 pIC50 1700 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4445-4448 [PMID:15357969]
fatty acid binding protein 3/Fatty acid binding protein muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3344] [GtoPdb: 2533] [UniProtKB: P05413]
ChEMBL In vitro inhibitory concentration against heart and muscle fatty acid binding protein(H-FABP) B 5.59 pIC50 2600 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4445-4448 [PMID:15357969]
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255]
ChEMBL Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay B 8.01 pEC50 9.8 nM EC50 US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (null)
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay B 5.82 pIC50 1500 nM IC50 Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay B 5.13 pIC50 7400 nM IC50 Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay B 4.52 pIC50 30000 nM IC50 Med Chem Res (2013) 22: 3126-3133
TLR2/Toll-like receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4163] [GtoPdb: 1752] [UniProtKB: O60603]
ChEMBL Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells F 5.3 pIC50 5000 nM IC50 J. Med. Chem. (2006) 49: 1754-1765 [PMID:16509590]
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842]
GtoPdb - - 5.3 pEC50 - - - J Biol Chem (2003) 278: 11303-11 [PMID:12496284];
Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875];
Nature (2003) 422: 173-6 [PMID:12629551]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]