palmitic acid [Ligand Id: 1055] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL82293 (Cetyl acid, Cetylic acid, FEMA NO. 2832, IMEX C 1498, KORTACID 1698, LOXIOL EP 278, N-hexadecanoic acid, NSC-5030, Palmitate, Palmitic acid, Prifac-2960, Pristerene-4934) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method | B | 4.99 | pIC50 | 10150 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3315-3319 [PMID:30220607] |
| fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
| ChEMBL | Binding affinity against Adipocyte lipid binding protein | B | 4.08 | pKd | 83000 | nM | Kd | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
| ChEMBL | Displacement of 1,8-ANS from aFABP by fluorescence based-assay | B | 6.47 | pKi | 336 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
| ChEMBL | In vitro inhibitory concentration against adipocyte fatty acid binding protein(A-FABP) | B | 6.03 | pIC50 | 930 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
| fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469] | ||||||||
| ChEMBL | Binding affinity to human kFABP | B | 6.1 | pKd | 802 | nM | Kd | J Med Chem (2006) 49: 5013-5017 [PMID:16884313] |
| ChEMBL | Displacement of 1,8-ANS from eFABP by fluorescence based-assay | B | 6.1 | pKi | 802 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3511-3515 [PMID:17502136] |
| ChEMBL | In vitro inhibitory concentration against epithelial fatty acid binding protein(E-FABP) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
| fatty acid binding protein 2/Fatty acid binding protein intestinal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879] [GtoPdb: 2532] [UniProtKB: P12104] | ||||||||
| ChEMBL | Binding affinity against Fatty acid-binding protein | B | 5.43 | pKd | -5.43 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
| ChEMBL | In vitro inhibitory concentration against intestinal fatty acid binding protein(I-FABP) | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
| fatty acid binding protein 3/Fatty acid binding protein muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3344] [GtoPdb: 2533] [UniProtKB: P05413] | ||||||||
| ChEMBL | In vitro inhibitory concentration against heart and muscle fatty acid binding protein(H-FABP) | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4445-4448 [PMID:15357969] |
| Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255] | ||||||||
| ChEMBL | Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay | F | 8.01 | pEC50 | 9.8 | nM | EC50 | US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (null) |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay | B | 5.82 | pIC50 | 1500 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| ChEMBL | Agonist activity at recombinant human PPARalpha LBD (168 to 468 residues) expressed in African green monkey COS-1 cells incubated for 18 hrs by luciferase reporter gene assay | B | 4.46 | pEC50 | 35000 | nM | EC50 | Eur J Med Chem (2018) 155: 736-753 [PMID:29940464] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay | B | 5.13 | pIC50 | 7400 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay | B | 4.52 | pIC50 | 30000 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by photometric method | B | 5.06 | pIC50 | 8800 | nM | IC50 | J Nat Prod (2020) 83: 1598-1610 [PMID:32255628] |
| TLR2/Toll-like receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4163] [GtoPdb: 1752] [UniProtKB: O60603] | ||||||||
| ChEMBL | Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells | F | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2006) 49: 1754-1765 [PMID:16509590] |
| TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842] | ||||||||
| GtoPdb | - | - | 5.3 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11303-11 [PMID:12496284]; Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875]; Nature (2003) 422: 173-6 [PMID:12629551] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
