L-α-methyldopa

Ligand id: 5217

Name: L-α-methyldopa

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 103.78
Molecular weight 211.08
XLogP -1.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1962))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
International Nonproprietary Names
INN number INN
1110 methyldopa
Synonyms
Aldomet® | Aldoril® | Dopamet® | L-α-Methyl-3,4-dihydroxyphenylalanine
Comments
L-α-methyldopa is metabolised to α-methylnorepinephrine in the brain, the metabolite being a selective agonist of α2 adrenoceptors. Clinical L-α-methyldopa use has largely been replaced by safer alternatives.
Database Links
CAS Registry No. 555-30-6
ChEBI CHEBI:61058
ChEMBL Ligand CHEMBL459
DrugBank Ligand DB00968
GtoPdb PubChem SID 178101902
PubChem CID 38853
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Wikipedia Methyldopa

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Tocris
L-(-)-α-Methyldopa
Cat. No. 0584