Ligand id: 5217

Name: L-α-methyldopa

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 103.78
Molecular weight 211.08
XLogP -1.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Methyldopa is metabolised to α-methylnorepinephrine, which likely activates inhibitory α2-adrenoceptors in the central nervous system. This action effects a reduction in sympathetic tone and total peripheral resistance which leads to reduced blood pressure. However, we have been unable to find affinity data for this drug to substantiate its MMOA.