PG 99-465 [Ligand Id: 2272] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586] | ||||||||
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 7.1 | pEC50 | 71.3 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 6.7 | pIC50 | 200 | nM | IC50 | Peptides (2000) 21: 1543-9 [PMID:11068102] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 5.5 | pEC50 | >3000 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 8.1 | pEC50 | 8.04 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] | ||||||||
| GtoPdb | inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor | - | 7.6 | pIC50 | 22.9 | nM | IC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Peptides (2000) 21: 1543-9 [PMID:11068102] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 8.3 | pEC50 | 4.9 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor | - | 8.4 | pEC50 | 4.4 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
