tolazamide   Click here for help

GtoPdb Ligand ID: 6847

Synonyms: tolazolamide | Tolinase®
Approved drug
tolazamide is an approved drug (FDA (1986))
Compound class: Synthetic organic
Comment: A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 (KCNJ11) potassium channel activity.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 86.89
Molecular weight 311.13
XLogP 2.69
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CCCCCC1
Isomeric SMILES O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CCCCCC1
InChI InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChI Key OUDSBRTVNLOZBN-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1986))
IUPAC Name Click here for help
1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea
International Nonproprietary Names Click here for help
INN number INN
1296 tolazamide
Synonyms Click here for help
tolazolamide | Tolinase®
Database Links Click here for help
CAS Registry No. 1156-19-0
ChEMBL Ligand CHEMBL817
DrugBank Ligand DB00839
DrugCentral Ligand 2694
GtoPdb PubChem SID 178103453
PubChem CID 5503
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Wikipedia Tolazamide