ChEMBL ligand: CHEMBL417990 (Bicuculline, (+)-Bicuculline)
GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88] This target only has 0 pki data point 1 CHEMBL417990_lig_chart_1 GABA-A receptor; anion channel Human There should be some charts here, you may need to enable JavaScript!
GABAA receptor γ1 subunit/GABA receptor gamma-1 subunit in Rat [ChEMBL: CHEMBL296] [GtoPdb: 413] [UniProtKB: P23574] This target only has 0 pki data point 2 CHEMBL417990_lig_chart_2 GABA receptor gamma-1 subunit Rat There should be some charts here, you may need to enable JavaScript!
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952] This target only has 0 pki data point 3 CHEMBL417990_lig_chart_3 KCa2.1 Human There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] This target only has 0 pki data point 4 CHEMBL417990_lig_chart_4 KCa2.2 Rat There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88]
ChEMBL	Binding affinity in vivo for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]-GABA agonist from rat brain preparations after iv injection.	B	4.36	pIC50	44000	nM	IC50	J. Med. Chem. (1992) 35: 4092-4097 [PMID:1331456]
ChEMBL	Displacement of [3H]GABA from gamma-aminobutyric-acid A (GABA-A) receptor	B	4.82	pIC50	15000	nM	IC50	J. Med. Chem. (1992) 35: 1969-1977 [PMID:1317920]
ChEMBL	Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.	F	5.21	pIC50	6200	nM	IC50	J. Med. Chem. (1992) 35: 4092-4097 [PMID:1331456]
GABAA receptor γ1 subunit/GABA receptor gamma-1 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL296] [GtoPdb: 413] [UniProtKB: P23574]
ChEMBL	Percent displacement of [3H]GABA at Gamma-aminobutyric acid receptor in rat brain membranes at 0.01 uM	B	5.42	pIC50	3800	nM	IC50	J. Med. Chem. (1980) 23: 1142-1144 [PMID:7420361]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb	-	-	4.8	pIC50	16000	nM	IC50	Br. J. Pharmacol. (2000) 129: 991-9 [PMID:10696100]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb	-	-	4.6	pIC50	-	-	-	Br. J. Pharmacol. (2000) 129: 991-9 [PMID:10696100]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]