ChEMBL ligand: CHEMBL1138 (Ezetimiba, Ezetimibe, Ezetimibe component of k-924, Ezetimibe component of liptruzet, Ezetimibe component of nexlizet, Ezetimibe component of roszet, Ezetimibe component of vytorin, Ezetrol, MK0653, NSC-758923, SCH-58235, SCH58235, Zetia)
Sodium/bile acid and sulphated solute cotransporter 1/Hepatic sodium/bile acid cotransporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
NPC1 like intracellular cholesterol transporter 1/NPC1-like intracellular cholesterol transporter 1 in Human [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9] NPC1 like intracellular cholesterol transporter 1/NPC1-like intracellular cholesterol transporter 1 in Rat [ChEMBL: CHEMBL5161] [GtoPdb: 2629] [UniProtKB: Q6T3U3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sodium/bile acid and sulphated solute cotransporter 1/Hepatic sodium/bile acid cotransporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	Binding affinity to NTCP (unknown origin)	B	4.6	pKi	25000	nM	Ki	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
NPC1 like intracellular cholesterol transporter 1/NPC1-like intracellular cholesterol transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
GtoPdb	Measure of ezetimibe glucuronide binding to NPC1L1	-	6.66	pKd	220	nM	Kd	Proc Natl Acad Sci USA (2005) 102: 8132-7 [PMID:15928087]
ChEMBL	Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assay	B	6.43	pIC50	370	nM	IC50	Eur J Med Chem (2022) 230: 114111-114111 [PMID:35063734]
NPC1 like intracellular cholesterol transporter 1/NPC1-like intracellular cholesterol transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5161] [GtoPdb: 2629] [UniProtKB: Q6T3U3]
ChEMBL	Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membrane	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2008) 18: 546-553 [PMID:18063367]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]