ChEMBL ligand: CHEMBL1617 (L-105, Normix, NSC-758957, Rifacol, Rifamycin l 105, Rifaxidin, Rifaximin, Rifaximina, Rifaximine, Targaxan, Xifaxan, Xifaxanta, Xifaxsan)
Pregnane X receptor in Human [ChEMBL: CHEMBL3401] [GtoPdb: 606] [UniProtKB: O75469] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Pregnane X receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3401] [GtoPdb: 606] [UniProtKB: O75469]
ChEMBL	Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximin	B	4.95	pEC50	11200	nM	EC50	Eur J Med Chem (2015) 103: 551-562 [PMID:26408814]
ChEMBL	Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by dual-luciferase reporter gene assay	B	5.4	pEC50	4000	nM	EC50	Eur J Med Chem (2014) 73: 126-134 [PMID:24388834]
ChEMBL	Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assay	B	5.66	pEC50	2200	nM	EC50	J Med Chem (2011) 54: 4590-4599 [PMID:21599020]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]