iberdomide   Click here for help

GtoPdb Ligand ID: 9618

Synonyms: CC-220 | compound 6 [PMID: 28425720]
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Iberdomide (CC-220) is a novel cereblon modulator [3], functionally akin to lenalidomide and pomalidomide.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.36
No. Lipinski's rules broken 0
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Canonical SMILES O=C1CCC(C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1
Isomeric SMILES O=C1CC[C@@H](C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1
InChI InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10632 iberdomide
Synonyms Click here for help
CC-220 | compound 6 [PMID: 28425720]
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9681222
Reactome Reaction Reactome logo R-HSA-9681169
Other databases
GtoPdb PubChem SID 340590248
PubChem CID 67335295
RCSB PDB Ligand 8W7
Search Google for chemical match using the InChIKey IXZOHGPZAQLIBH-NRFANRHFSA-N
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UniChem Compound Search for chemical match using the InChIKey IXZOHGPZAQLIBH-NRFANRHFSA-N
UniChem Connectivity Search for chemical match using the InChIKey IXZOHGPZAQLIBH-NRFANRHFSA-N