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Synonyms: CC-220 | compound 6 [PMID: 28425720]
Compound class: Synthetic organic
Comment: Iberdomide (CC-220) is a novel cereblon modulator , functionally akin to lenalidomide and pomalidomide.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bjorklund CC, Lu L, Kang J, Hagner PR, Havens CG, Amatangelo M, Wang M, Ren Y, Couto S, Breider M et al.. (2015)
Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.
Blood Cancer J, 5: e354. [PMID:26430725]
2. Cai X, Qiao Y, Diao C, Xu X, Chen Y, Du S, Liu X, Liu N, Yu S, Chen D et al.. (2014)
Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population.
PLoS ONE, 9 (10): e108661. [PMID:25271777]
3. Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G et al.. (2018)
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J Med Chem, 61 (2): 535-542. [PMID:28425720]