iberdomide

Ligand id: 9618

Name: iberdomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CC-220 binds cereblon with higher affinity than lenalidomide or pomalidomide [3].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
cereblon Hs None Binding 7.2 pIC50 - 3
pIC50 7.2 (IC50 6x10-8 M) [3]
Description: Measuring displacement of a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN by CC-220.