iberdomide

Ligand id: 9618

Name: iberdomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK
Immunopharmacology Comments
CC-220 is a novel cereblon-binding immunomodulator [3], functionally akin to lenalidomide and pomalidomide.
Immunopharmacology Disease
Disease X-Refs Comment References
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
 Phase 2 clinical candidate for SLE- see NCT03161483
Multiple myeloma Disease Ontology: DOID:9538
OMIM: 254500
 Phase 1/2 clinical candidate for MM- see NCT03161483