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ChEMBL ligand: CHEMBL306700 (Viloxazin, Viloxazine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
ChEMBL | Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT | B | 6.81 | pKd | 155 | nM | Kd | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
ChEMBL | Inhibition of [3H]- DA reuptake into rat striatal synaptosomes | B | 4.32 | pKi | 48000 | nM | Ki | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter | B | 6.81 | pKd | 155 | nM | Kd | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] | ||||||||
ChEMBL | Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes | B | 6.77 | pKi | 170 | nM | Ki | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT | B | 4.76 | pKd | 17300 | nM | Kd | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes | B | 4.78 | pKi | 16500 | nM | Ki | Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]