viloxazine [Ligand Id: 11502] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL306700 (Viloxazin, Viloxazine)
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT B 6.81 pKd 155 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Inhibition of [3H]- DA reuptake into rat striatal synaptosomes B 4.32 pKi 48000 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter B 6.81 pKd 155 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes B 6.77 pKi 170 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT B 4.76 pKd 17300 nM Kd Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes B 4.78 pKi 16500 nM Ki Bioorg. Med. Chem. Lett. (1998) 8: 487-492 [PMID:9871604]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]