ramipril [Ligand Id: 6339] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1168 (Altace, Tritace, HOE 498, Ramipril, C09AA05, Lopace, Ranace, HOE-498)
  • Angiotensin-converting enzyme in Human [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
  • Angiotensin-converting enzyme in Rabbit [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1168_lig_chart_1 Angiotensin-converting enzyme HumanRabbit
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 7.6 pIC50 26 nM IC50 Arzneimittelforschung (1984) 34: 1402-6 [PMID:6097265]
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 8.4 pIC50 4 nM IC50 J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins B 6.6 pIC50 253 nM IC50 Bioorg. Med. Chem. (2013) 21: 4485-4493 [PMID:23777825]
ChEMBL Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method B 6.6 pIC50 253 nM IC50 Bioorg. Med. Chem. (2015) 23: 3526-3533 [PMID:25922179]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]