alogliptin [Ligand Id: 6319] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL376359 (Alogliptin, Vipidia)
  • Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
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  • dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
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  • fibroblast activation protein alpha/Fibroblast activation protein alpha in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
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  • prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL Inhibition of human DPP2 using Lys-Ala-AMC as substrate by fluorimetric analysis B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL Inhibition of DPP2 (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2014) 5: 1700-1707
ChEMBL Inhibition of QPP (unknown origin) preincubated for 30 mins followed by Nle-Pro-AMC addition measured for 50 mins by continuous fluorescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP4 in human Caco2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate after 1 hr by fluorescence assay B 7.62 pIC50 24 nM IC50 Bioorg. Med. Chem. (2013) 21: 2795-2825 [PMID:23623674]
ChEMBL Inhibition of human DPP4 by fluorimetry B 8 pIC50 <10 nM IC50 Eur. J. Med. Chem. (2009) 44: 3318-3322 [PMID:19375196]
ChEMBL Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay B 8.12 pIC50 7.6 nM IC50 ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL Inhibition of human recombinant DPP4 pre-incubated with compound for 15 mins before substrate addition by luminescence assay B 8.15 pIC50 7 nM IC50 ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL Inhibition of human DPP4 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2011) 54: 510-524 [PMID:21186796]
ChEMBL Inhibition of human DPP4 B 8.16 pIC50 6.9 nM IC50 MedChemComm (2014) 5: 1700-1707
ChEMBL Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assay B 8.28 pIC50 5.3 nM IC50 J Med Chem (2017) 60: 6480-6515 [PMID:28421763]
ChEMBL Inhibition of human DPP4 using A-P-7-amido-4-trifluoromethylcoumarin as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins B 8.4 pIC50 4 nM IC50 Bioorg Med Chem (2018) 26: 903-912 [PMID:29373269]
ChEMBL Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL Inhibition of DPP4 after 20 mins by fluorescence assay B 8.47 pIC50 3.4 nM IC50 Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
ChEMBL Inhibition of human DPP4 after 10 mins B 8.47 pIC50 3.4 nM IC50 Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
GtoPdb - - 8.5 pIC50 3.4 nM IC50 Eur J Med Chem (2012) 52: 205-12 [PMID:22475866]
ChEMBL Inhibition of human DPP-4 using Gly-pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins B 8.82 pIC50 1.5 nM IC50 Eur. J. Med. Chem. (2013) 68: 312-320 [PMID:23994324]
ChEMBL Inhibition of DPP4 in human plasma assessed as formation of 7-amino-4-methylcoumarin from glycyl-L-proline 4-methylcoumaryl-7-amide by fluorescence assay B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. (2011) 19: 5490-5499 [PMID:21865048]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
ChEMBL Inhibition of DPP9 B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL Inhibition of human recombinant DPP9 pre-incubated with compound for 15 mins before substrate addition by luminescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL Inhibition of DPP9 (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2014) 5: 1700-1707
ChEMBL Inhibition of DPP9 (unknown origin) preincubated for 20 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL Inhibition of DPP9 after 20 mins by fluorescence assay B 4.6 pIC50 >25000 nM IC50 Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
ChEMBL Inhibition of DPP9 B 4.6 pIC50 >25000 nM IC50 Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
ChEMBL Inhibition of DPP8 B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL Inhibition of human DPP8 B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2011) 54: 510-524 [PMID:21186796]
ChEMBL Inhibition of DPP8 (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2014) 5: 1700-1707
ChEMBL Inhibition of recombinant DPP8 (unknown origin) preincubated for 20 mins followed by Ala-Pro-AFC addition measured for 40 mins by continuous fluorescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL Inhibition of human recombinant DPP8 pre-incubated with compound for 15 mins before substrate addition by luminescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL Inhibition of DPP8 B 4.6 pIC50 >25000 nM IC50 Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
ChEMBL Inhibition of DPP8 after 20 mins by fluorescence assay B 4.6 pIC50 >25000 nM IC50 Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL Inhibition of FAPalpha B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL Inhibition of FAP (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2014) 5: 1700-1707
ChEMBL Inhibition of FAP (unknown origin) preincubated for 20 mins followed by Nle-Pro-AMC addition measured for 40 mins by continuous fluorescence assay B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
ChEMBL Inhibition of PREP (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2014) 5: 1700-1707

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]