ChEMBL ligand: CHEMBL376359 (Alogliptin, Vipidia)
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] There should be some charts here, you may need to enable JavaScript!
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884] There should be some charts here, you may need to enable JavaScript!
prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dipeptidyl-peptidase 7/Dipeptidyl peptidase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4]
ChEMBL	Inhibition of human DPP2 using Lys-Ala-AMC as substrate by fluorimetric analysis	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of DPP2 (unknown origin)	B	4	pIC50	>100000	nM	IC50	MedChemComm (2014) 5: 1700-1707
ChEMBL	Inhibition of QPP (unknown origin) preincubated for 30 mins followed by Nle-Pro-AMC addition measured for 50 mins by continuous fluorescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL	Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry	B	7.55	pKd	28.5	nM	Kd	J Med Chem (2016) 59: 7466-7477 [PMID:27438064]
ChEMBL	Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis	B	8.62	pKd	2.4	nM	Kd	J Med Chem (2016) 59: 7466-7477 [PMID:27438064]
ChEMBL	Inhibition of DPP4 in human Caco2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate after 1 hr by fluorescence assay	B	7.62	pIC50	24	nM	IC50	Bioorg. Med. Chem. (2013) 21: 2795-2825 [PMID:23623674]
ChEMBL	Inhibition of human DPP4 by fluorimetry	B	8	pIC50	<10	nM	IC50	Eur. J. Med. Chem. (2009) 44: 3318-3322 [PMID:19375196]
ChEMBL	Inhibition of human DPP4 preincubated for 30 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay	B	8.12	pIC50	7.6	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL	Inhibition of human recombinant DPP4 (39 to 766 residues) using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assay	B	8.15	pIC50	7	nM	IC50	J Med Chem (2016) 59: 7466-7477 [PMID:27438064]
ChEMBL	Inhibition of human DPP4	B	8.15	pIC50	7	nM	IC50	J. Med. Chem. (2011) 54: 510-524 [PMID:21186796]
ChEMBL	Inhibition of human recombinant DPP4 pre-incubated with compound for 15 mins before substrate addition by luminescence assay	B	8.15	pIC50	7	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL	Inhibition of human DPP4	B	8.16	pIC50	6.9	nM	IC50	MedChemComm (2014) 5: 1700-1707
ChEMBL	Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assay	B	8.28	pIC50	5.3	nM	IC50	J Med Chem (2017) 60: 6480-6515 [PMID:28421763]
ChEMBL	Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interval for 20 mins by fluorometic method	B	8.35	pIC50	4.46	nM	IC50	Eur J Med Chem (2019) 180: 509-523 [PMID:31336309]
ChEMBL	Inhibition of DPP4 in human Caco-2 cells using AP-AFC as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 10 mins by fluorescence based analysis	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2020) 208: 112850-112850 [PMID:32987315]
ChEMBL	Inhibition of DPP4 in human plasma using Gly-Pro-AMC as substrate by fluorimetric analysis	B	8.4	pIC50	4	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of human DPP4 using A-P-7-amido-4-trifluoromethylcoumarin as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2018) 26: 903-912 [PMID:29373269]
ChEMBL	Inhibition of human DPP4 after 10 mins	B	8.47	pIC50	3.4	nM	IC50	Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
ChEMBL	Inhibition of DPP4 after 20 mins by fluorescence assay	B	8.47	pIC50	3.4	nM	IC50	Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
GtoPdb	-	-	8.5	pIC50	3.4	nM	IC50	Eur J Med Chem (2012) 52: 205-12 [PMID:22475866]
ChEMBL	Inhibition of human recombinant DPP4 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay	B	8.51	pIC50	3.1	nM	IC50	Eur J Med Chem (2021) 225: 113765-113765 [PMID:34399391]
ChEMBL	Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay	B	8.57	pIC50	2.7	nM	IC50	Bioorg Med Chem (2019) 27: 644-654 [PMID:30642693]
ChEMBL	Inhibition of human DPP-4 using Gly-pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins	B	8.82	pIC50	1.5	nM	IC50	Eur. J. Med. Chem. (2013) 68: 312-320 [PMID:23994324]
ChEMBL	Inhibition of DPP4 in human plasma assessed as formation of 7-amino-4-methylcoumarin from glycyl-L-proline 4-methylcoumaryl-7-amide by fluorescence assay	B	9	pIC50	1	nM	IC50	Bioorg. Med. Chem. (2011) 19: 5490-5499 [PMID:21865048]
dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2]
ChEMBL	Inhibition of DPP9 (unknown origin) preincubated for 20 mins followed by Gly-Pro-AMC addition measured for 50 mins by continuous fluorescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL	Inhibition of DPP9	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of human recombinant DPP9 pre-incubated with compound for 15 mins before substrate addition by luminescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL	Inhibition of DPP9 (unknown origin)	B	4	pIC50	>100000	nM	IC50	MedChemComm (2014) 5: 1700-1707
ChEMBL	Inhibition of DPP9 (unknown origin)	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2020) 208: 112850-112850 [PMID:32987315]
ChEMBL	Inhibition of DPP9 after 20 mins by fluorescence assay	B	4.6	pIC50	>25000	nM	IC50	Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
ChEMBL	Inhibition of DPP9	B	4.6	pIC50	>25000	nM	IC50	Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
ChEMBL	Inhibition of human recombinant DPP9 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay	B	7	pIC50	>100	nM	IC50	Eur J Med Chem (2021) 225: 113765-113765 [PMID:34399391]
dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1]
ChEMBL	Inhibition of recombinant DPP8 (unknown origin) preincubated for 20 mins followed by Ala-Pro-AFC addition measured for 40 mins by continuous fluorescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
ChEMBL	Inhibition of human DPP8	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2011) 54: 510-524 [PMID:21186796]
ChEMBL	Inhibition of DPP8	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of human recombinant DPP8 pre-incubated with compound for 15 mins before substrate addition by luminescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 921-926 [PMID:25147615]
ChEMBL	Inhibition of DPP8 (unknown origin)	B	4	pIC50	>100000	nM	IC50	MedChemComm (2014) 5: 1700-1707
ChEMBL	Inhibition of DPP8 (unknown origin)	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2020) 208: 112850-112850 [PMID:32987315]
ChEMBL	Inhibition of DPP8 after 20 mins by fluorescence assay	B	4.6	pIC50	>25000	nM	IC50	Eur. J. Med. Chem. (2011) 46: 71-76 [PMID:21106276]
ChEMBL	Inhibition of DPP8	B	4.6	pIC50	>25000	nM	IC50	Eur. J. Med. Chem. (2012) 52: 205-212 [PMID:22475866]
ChEMBL	Inhibition of human recombinant DPP8 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay	B	7	pIC50	>100	nM	IC50	Eur J Med Chem (2021) 225: 113765-113765 [PMID:34399391]
fibroblast activation protein alpha/Fibroblast activation protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4683] [GtoPdb: 2365] [UniProtKB: Q12884]
ChEMBL	Inhibition of FAPalpha	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5864-5883 [PMID:22938786]
ChEMBL	Inhibition of FAP (unknown origin)	B	4	pIC50	>100000	nM	IC50	MedChemComm (2014) 5: 1700-1707
ChEMBL	Inhibition of FAP (unknown origin) preincubated for 20 mins followed by Nle-Pro-AMC addition measured for 40 mins by continuous fluorescence assay	B	4	pIC50	>100000	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 498-501 [PMID:27190600]
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
ChEMBL	Inhibition of PREP (unknown origin)	B	4	pIC50	>100000	nM	IC50	MedChemComm (2014) 5: 1700-1707

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]