H+ [Ligand Id: 2346] activity data from GtoPdb

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

  • Kir1.1 in Rat [GtoPdb: 429] [UniProtKB: P35560]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 Kir1.1 Rat
There should be some charts here, you may need to enable JavaScript!
  • Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
  • 7.09
2 _lig_chart_2 Kir2.3 Human
There should be some charts here, you may need to enable JavaScript!
  • Kir2.4 in Human [GtoPdb: 433] [UniProtKB: Q9UNX9]
  • This target only has 1 pki data point
  • 7.14
3 _lig_chart_3 Kir2.4 Human
There should be some charts here, you may need to enable JavaScript!
  • Kir4.1 in Rat [GtoPdb: 438] [UniProtKB: P49655]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 Kir4.1 Rat
There should be some charts here, you may need to enable JavaScript!
  • Kir4.2 in Rat [GtoPdb: 439] [UniProtKB: Q91ZF1]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 Kir4.2 Rat
There should be some charts here, you may need to enable JavaScript!
  • TRPM5 in Human [GtoPdb: 497] [UniProtKB: Q9NZQ8]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 TRPM5 Human
There should be some charts here, you may need to enable JavaScript!
  • TRPV1 in Human [GtoPdb: 507] [UniProtKB: Q8NER1]
  • This target only has 0 pki data point
  • 0
7 _lig_chart_7 TRPV1 Human
There should be some charts here, you may need to enable JavaScript!
  • ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
  • This target only has 0 pki data point
  • 0
8 _lig_chart_8 ZAC Human
There should be some charts here, you may need to enable JavaScript!
  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
  • This target only has 0 pki data point
  • 0
9 _lig_chart_9 ASIC1 Human
There should be some charts here, you may need to enable JavaScript!
  • ASIC2 in Human [GtoPdb: 685] [UniProtKB: Q16515]
  • This target only has 0 pki data point
  • 0
10 _lig_chart_10 ASIC2 Human
There should be some charts here, you may need to enable JavaScript!
  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
  • This target only has 0 pki data point
  • 0
11 _lig_chart_11 ASIC3 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kir1.1 in Rat [GtoPdb: 429] [UniProtKB: P35560]
GtoPdb - - 6.8 pIC50 - - - J Biol Chem (1996) 271: 17261-6 [PMID:8663367];
Am J Physiol (1995) 268: C1173-8 [PMID:7762610];
Biophys J (2003) 84: 910-21 [PMID:12547773]
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
GtoPdb - - 6.77 pKi - - - J Physiol (Lond.) (1999) 516 ( Pt 3): 699-710 [PMID:10200419];
J Biol Chem (2000) 275: 31573-80 [PMID:10896660]
GtoPdb - - 7.4 pKi - - - Neuron (1995) 15: 1157-68 [PMID:7576658];
J Physiol (Lond.) (1999) 516 ( Pt 3): 699-710 [PMID:10200419]
Kir2.4 in Human [GtoPdb: 433] [UniProtKB: Q9UNX9]
GtoPdb - - 7.14 pKi - - - Am J Physiol, Cell Physiol (2000) 279: C771-84 [PMID:10942728]
Kir4.1 in Rat [GtoPdb: 438] [UniProtKB: P49655]
GtoPdb - - 6.1 pEC50 - - - J Physiol (Lond.) (2001) 532: 359-67 [PMID:11306656];
J Biol Chem (2000) 275: 16404-7 [PMID:10764726]
Kir4.2 in Rat [GtoPdb: 439] [UniProtKB: Q91ZF1]
GtoPdb - - 7.1 pEC50 - - - J Physiol (Lond.) (2001) 532: 359-67 [PMID:11306656]
TRPM5 in Human [GtoPdb: 497] [UniProtKB: Q9NZQ8]
GtoPdb - - 3.2 pIC50 630000 nM IC50
TRPV1 in Human [GtoPdb: 507] [UniProtKB: Q8NER1]
GtoPdb - - 5.4 pEC50 3980 nM EC50
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
GtoPdb - - 5.6 pEC50 - - - Biochem Pharmacol (2016) 103: 109-17 [PMID:26872532]
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
GtoPdb - - 6.2 pEC50 ~630 nM EC50
GtoPdb - - 6.8 pEC50 ~160 nM EC50
ASIC2 in Human [GtoPdb: 685] [UniProtKB: Q16515]
GtoPdb - - 5 pEC50 ~10000 nM EC50
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 4.3 pEC50 ~50000 nM EC50
GtoPdb - - 6.7 pEC50 ~200 nM EC50

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.