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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 412 | 17q25.1 | ZACN | zinc activated ion channel | 1-2 |
Previous and Unofficial Names ![]() |
ZAC1 | LGICZ1 | L2 | LGICZ | zinc activated ligand-gated ion channel |
Database Links ![]() |
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Alphafold | Q401N2 (Hs) |
CATH/Gene3D | 2.70.170.10 |
Ensembl Gene | ENSG00000186919 (Hs) |
Entrez Gene | 353174 (Hs) |
Human Protein Atlas | ENSG00000186919 (Hs) |
KEGG Gene | hsa:353174 (Hs) |
OMIM | 610935 (Hs) |
Pharos | Q401N2 (Hs) |
RefSeq Nucleotide | NM_180990 (Hs) |
RefSeq Protein | NP_851321 (Hs) |
UniProtKB | Q401N2 (Hs) |
Wikipedia | ZACN (Hs) |
Functional Characteristics ![]() |
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Outwardly rectifying current (both constitutive and evoked by Zn2+) |
Ion Selectivity and Conductance Comments |
ZAC is cation-selective [1] |
Natural/Endogenous Ligands ![]() |
Cu2+ |
H+ |
Zn2+ |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ZAC is spontaneously active and mediates an outwardly rectifying conductance. In whole cell recordings, the spontaneous current increases in magnitude with time [1]. The magnitude of the Zn2+-activated current does not correlate with that of the spontaneous current [1]. |
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(+)-Tubocurarine (100 μM) also blocks spontaneous currents mediated by ZAC [1]. Although tabulated as an antagonist, it remains possible that (+)-tubocurarine acts as a channel blocker. |
Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution ![]() |
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General Comments |
The ZAC subunit does not appear to exist in the mouse or rat genomes [1]. Although tabulated as an antagonist, it is possible that |
1. Davies PA, Wang W, Hales TG, Kirkness EF. (2003) A novel class of ligand-gated ion channel is activated by Zn2+. J Biol Chem, 278 (2): 712-7. [PMID:12381728]
2. Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T. (2005) Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. Biochem Biophys Res Commun, 335 (2): 277-85. [PMID:16083862]
3. Madjroh N, Mellou E, Davies PA, Söderhielm PC, Jensen AA. (2021) Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC). Biochem Pharmacol, 193: 114782. [PMID:34560054]
4. Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. (2016) Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol, 103: 109-17. [PMID:26872532]