von Willebrand factor

Ligand id: 6755

Name: von Willebrand factor

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (2015))
Synonyms
Vonvendi® | vWF
Comments
Details of the structure of von Willebrand factor (vWF) are available in its UniProt record. The pre-pro peptide is 2813 amino acids, with residues 1-22 being the signal peptide, residues 23-763 forming von Willebrand antigen 2, and the remaining 2050 residues (764-2813) constituting vWF. The Uniprot record also provides details of mutations underlying defective vWF activity in the three subtypes of von Willebrand disease.
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
VWF von Willebrand factor Human von Willebrand factor F8VWF
Database Links
CATH/Gene3D 3.40.50.410
DrugBank Target P04275 (Hs)
Ensembl Gene ENSG00000110799 (Hs)
Entrez Gene 7450 (Hs)
GtoPdb PubChem SID 178103366
Human Protein Atlas ENSG00000110799 (Hs)
Immunopaedia Search von Willebrand factor
UniProtKB P04275 (Hs)
Wikipedia Von_Willebrand_factor