Synonyms: Vonvendi® | vWF
von Willebrand factor is an approved drug (FDA (2015))
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Details of the structure of von Willebrand factor (vWF) are available in its UniProt record. The pre-pro peptide is 2813 amino acids, with residues 1-22 being the signal peptide, residues 23-763 forming von Willebrand antigen 2, and the remaining 2050 residues (764-2813) constituting vWF. The Uniprot record also provides details of mutations underlying defective vWF activity in the three subtypes of von Willebrand disease.
Species: Human
|
Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Ligands at integrin αIIbβ3 | fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), fibronectin (FN1, P02751), von Willebrand factor (VWF, P04275), vitronectin (VTN, P04004), thrombospondin | |
Ligands at integrin αVβ3 | vitronectin (VTN, P04004), fibronectin (FN1, P02751), fibrinogen (FGA, FGB, FGG, P02671, P02675, P02679), osteopontin (SPP1, P10451), von Willebrand factor (VWF, P04275), thrombospondin, tenascin |
Other ligands which bind to or alter the activity of this ligand | ||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||
|
Ligand mentioned in the following text fields |
Integrins comments |