apstatin [Ligand Id: 8803] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL311875
  • Leucine aminopeptidase 3/Leucine aminopeptidase in Human [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838]
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  • X-prolyl aminopeptidase 1/Xaa-Pro aminopeptidase 1 in Human [ChEMBL: CHEMBL3782] [GtoPdb: 1578] [UniProtKB: Q9NQW7]
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  • X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Human [ChEMBL: CHEMBL4610] [GtoPdb: 1579] [UniProtKB: O43895]
  • X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Rat [ChEMBL: CHEMBL2970] [GtoPdb: 1579] [UniProtKB: Q99MA2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Leucine aminopeptidase 3/Leucine aminopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3965] [GtoPdb: 1569] [UniProtKB: P28838]
ChEMBL Inhibition against Leucyl aminopeptidase from pig kidney. B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
X-prolyl aminopeptidase 1/Xaa-Pro aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3782] [GtoPdb: 1578] [UniProtKB: Q9NQW7]
ChEMBL Inhibition against cytosolic Aminopeptidase P from human heart. B 4.68 pIC50 21000 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
GtoPdb - - 4.68 pIC50 21000 nM IC50 J. Med. Chem. (1999) 42: 2394-402 [PMID:10395480]
ChEMBL Inhibition against Aminopeptidase P from human platelets. B 4.74 pIC50 18000 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4610] [GtoPdb: 1579] [UniProtKB: O43895]
GtoPdb - - 6.19 pKi 640 nM Ki J. Med. Chem. (1999) 42: 2394-402 [PMID:10395480]
ChEMBL Inhibition against membrane bound monkey aminopeptidase P B 5.21 pIC50 6100 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
ChEMBL Inhibition against membrane bound human aminopeptidase P B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
GtoPdb - - 5.54 pIC50 2900 nM IC50 J. Med. Chem. (1999) 42: 2394-402 [PMID:10395480]
X-prolyl aminopeptidase 2/Xaa-Pro aminopeptidase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2970] [GtoPdb: 1579] [UniProtKB: Q99MA2]
ChEMBL Activity against membrane bound rat aminopeptidase P B 5.39 pIC50 4100 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]
peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955]
ChEMBL Inhibition against Prolidase from pig kidney. B 5.31 pIC50 4900 nM IC50 J. Med. Chem. (1999) 42: 2394-2402 [PMID:10395480]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]