SUVN-911   

GtoPdb Ligand ID: 10700

Synonyms: compound 9h [PMID: 32026697]
Compound class: Synthetic organic
Comment: SUVN-911 is a novel, potent, selective and orally active antagonist of neuronal α4β2 nicotinic acetylcholine receptors [1]. It was designed by scientists at Suven Life Sciences as a potential anti-depressant drug. The disclosure report specifies the compound as the hydrochloride salt, so bioactivity data will have been generated using this form. We show the structure for the parent molecule in this entry.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 34.15
Molecular weight 224.07
XLogP 1.61
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES Clc1ccc(cn1)OCC1CC2C(N1)C2
Isomeric SMILES Clc1ccc(cn1)OCC1CC2C(N1)C2
InChI InChI=1S/C11H13ClN2O/c12-11-2-1-9(5-13-11)15-6-8-3-7-4-10(7)14-8/h1-2,5,7-8,10,14H,3-4,6H2
InChI Key PYSCVJMLJRHJGJ-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
IUPAC Name
3-[(6-chloropyridin-3-yl)oxymethyl]-2-azabicyclo[3.1.0]hexane
Synonyms
compound 9h [PMID: 32026697]
Database Links
GtoPdb PubChem SID 404859147
PubChem CID 53236401
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