Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL661 (Alprazolam, Alprazolam civ, Niravam, NSC-760140, U 31,889, U-31889, U-31,889, Xanax, Xanax xr) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
ChEMBL | Binding affinity to BRD4-BD1 by isothermal titration calorimetry | B | 5.61 | pKd | 2460 | nM | Kd | Bioorg Med Chem (2012) 20: 1878-1886 [PMID:22137933] |
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
ChEMBL | Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreas | B | 4.19 | pIC50 | 64000 | nM | IC50 | J Med Chem (1988) 31: 176-181 [PMID:3336017] |
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
ChEMBL | Displacement of [125I]gastrin from guinea pig gastric glands | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1988) 31: 176-181 [PMID:3336017] |
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit in Human [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O00591, P18505, O14764, P18507, P31644, P34903, Q8N1C3, P47869, P48169, Q99928, Q16445, P14867, P28472, P47870, P78334] | ||||||||
GtoPdb | - | - | 7.16 | pEC50 | 69 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
GtoPdb | - | - | 7.43 | pEC50 | 37 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
GtoPdb | - | - | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
GtoPdb | - | - | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
ChEMBL | Binding affinity was determined by displacement of [3H]flumazenil from rat cortex homogenates | F | 8.48 | pKi | 3.3 | nM | Ki | J Med Chem (2002) 45: 5043-5051 [PMID:12408715] |
GABAA receptor α1 subunit/GABA receptor alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1962] [GtoPdb: 404] [UniProtKB: P14867] | ||||||||
GtoPdb | - | - | 7.43 | pEC50 | 37 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
ChEMBL | Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 1 | B | 7.43 | pEC50 | 37 | nM | EC50 | J Med Chem (2002) 45: 5043-5051 [PMID:12408715] |
GABAA receptor α2 subunit/GABA receptor alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4956] [GtoPdb: 405] [UniProtKB: P47869] | ||||||||
GtoPdb | - | - | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
ChEMBL | Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2 | B | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2002) 45: 5043-5051 [PMID:12408715] |
GABAA receptor α3 subunit/GABA receptor alpha-3 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3026] [GtoPdb: 406] [UniProtKB: P34903] | ||||||||
GtoPdb | - | - | 7.16 | pEC50 | 69 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
ChEMBL | Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 3 | B | 7.16 | pEC50 | 69 | nM | EC50 | J Med Chem (2002) 45: 5043-5051 [PMID:12408715] |
GABAA receptor α5 subunit/GABA receptor alpha-5 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5112] [GtoPdb: 408] [UniProtKB: P31644] | ||||||||
GtoPdb | - | - | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2002) 45: 5043-51 [PMID:12408715] |
ChEMBL | Effective concentration against Gamma-aminobutyric acid A receptor, alpha 5 | B | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2002) 45: 5043-5051 [PMID:12408715] |
Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556] | ||||||||
ChEMBL | Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma | F | 4.66 | pIC50 | 22000 | nM | IC50 | J Med Chem (1993) 36: 580-590 [PMID:8496938] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]