SB209670 [Ligand Id: 3528] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL8823 (SB-209670) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] | ||||||||
| ChEMBL | Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cells | B | 9.37 | pKi | 0.43 | nM | Ki | J Med Chem (1996) 39: 1039-1048 [PMID:8676339] |
| ChEMBL | Inhibition of [125I]ET1 binding to cloned human ET-A receptor | B | 9.37 | pKi | 0.43 | nM | Ki | J Med Chem (1994) 37: 1553-1557 [PMID:8201588] |
| ChEMBL | Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (1997) 40: 3217-3227 [PMID:9379441] |
| ETA receptor in Rat [GtoPdb: 219] [UniProtKB: P26684] | ||||||||
| ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530] | ||||||||
| ChEMBL | Ability to displace endothelin ([125I]ET1) from human Endothelin B receptor | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1997) 40: 3217-3227 [PMID:9379441] |
| ChEMBL | Inhibitory activity against human Endothelin B receptor in chinese hamster ovary cells | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (1996) 39: 1039-1048 [PMID:8676339] |
| ChEMBL | Inhibition of [125I]ET1 binding to cloned human ET-B receptor | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (1994) 37: 1553-1557 [PMID:8201588] |
| ETB receptor in Rat [GtoPdb: 220] [UniProtKB: P21451] | ||||||||
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
