SB209670 [Ligand Id: 3528] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL8823 (SB-209670) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] | ||||||||
| ChEMBL | Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cells | B | 9.37 | pKi | 0.43 | nM | Ki | J Med Chem (1996) 39: 1039-1048 [PMID:8676339] |
| ChEMBL | Inhibition of [125I]ET1 binding to cloned human ET-A receptor | B | 9.37 | pKi | 0.43 | nM | Ki | J Med Chem (1994) 37: 1553-1557 [PMID:8201588] |
| ChEMBL | Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (1997) 40: 3217-3227 [PMID:9379441] |
| ETA receptor in Rat [GtoPdb: 219] [UniProtKB: P26684] | ||||||||
| ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530] | ||||||||
| ChEMBL | Ability to displace endothelin ([125I]ET1) from human Endothelin B receptor | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (1997) 40: 3217-3227 [PMID:9379441] |
| ChEMBL | Inhibitory activity against human Endothelin B receptor in chinese hamster ovary cells | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (1996) 39: 1039-1048 [PMID:8676339] |
| ChEMBL | Inhibition of [125I]ET1 binding to cloned human ET-B receptor | B | 7.83 | pKi | 14.7 | nM | Ki | J Med Chem (1994) 37: 1553-1557 [PMID:8201588] |
| ETB receptor in Rat [GtoPdb: 220] [UniProtKB: P21451] | ||||||||
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
