SB209670 [Ligand Id: 3528] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL8823 (SB-209670)
  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
  • ETA receptor in Rat [GtoPdb: 219] [UniProtKB: P26684]
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  • ETB receptor/Endothelin receptor ET-B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
  • ETB receptor in Rat [GtoPdb: 220] [UniProtKB: P21451]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cells B 9.37 pKi 0.43 nM Ki J Med Chem (1996) 39: 1039-1048 [PMID:8676339]
ChEMBL Inhibition of [125I]ET1 binding to cloned human ET-A receptor B 9.37 pKi 0.43 nM Ki J Med Chem (1994) 37: 1553-1557 [PMID:8201588]
ChEMBL Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor B 9.7 pKi 0.2 nM Ki J Med Chem (1997) 40: 3217-3227 [PMID:9379441]
ETA receptor in Rat [GtoPdb: 219] [UniProtKB: P26684]
ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
ChEMBL Ability to displace endothelin ([125I]ET1) from human Endothelin B receptor B 7.74 pKi 18 nM Ki J Med Chem (1997) 40: 3217-3227 [PMID:9379441]
ChEMBL Inhibitory activity against human Endothelin B receptor in chinese hamster ovary cells B 7.83 pKi 14.7 nM Ki J Med Chem (1996) 39: 1039-1048 [PMID:8676339]
ChEMBL Inhibition of [125I]ET1 binding to cloned human ET-B receptor B 7.83 pKi 14.7 nM Ki J Med Chem (1994) 37: 1553-1557 [PMID:8201588]
ETB receptor in Rat [GtoPdb: 220] [UniProtKB: P21451]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]