guanosine 5'-diphosphate [Ligand Id: 2410] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL384759
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  • P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fucosyltransferase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3146] [UniProtKB: Q11128]
ChEMBL Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine B 4.17 pIC50 67000 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 1809-1811 [PMID:11459637]
Fucosyltransferase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4985] [UniProtKB: Q9Y231]
ChEMBL Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting B 4.11 pKi 77900 nM Ki Bioorg. Med. Chem. (2014) 22: 6430-6437 [PMID:25438767]
ChEMBL Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting B 4.23 pIC50 59000 nM IC50 Bioorg. Med. Chem. (2014) 22: 6430-6437 [PMID:25438767]
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077]
ChEMBL Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production F 4.35 pEC50 45000 nM EC50 J. Med. Chem. (2006) 49: 5532-5543 [PMID:16942026]
Ras-related protein Rab-7a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105784] [UniProtKB: P51149]
ChEMBL Binding affinity to Rab7 GTPase L129F mutant (unknown origin) assessed as equilibrium dissociation constant B 6.96 pKd 109.2 nM Kd US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null)
ChEMBL Binding affinity to Rab7 GTPase V162M mutant (unknown origin) assessed as equilibrium dissociation constant B 7.04 pKd 92.12 nM Kd US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null)
ChEMBL Binding affinity to Rab7 GTPase N161T mutant (unknown origin) assessed as equilibrium dissociation constant B 7.42 pKd 37.62 nM Kd US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null)
ChEMBL Binding affinity to wild-type Rab7 (unknown origin) assessed as equilibrium dissociation constant B 7.59 pKd 25.83 nM Kd US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (null)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]