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ChEMBL ligand: CHEMBL384759 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Fucosyltransferase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3146] [UniProtKB: Q11128] | ||||||||
ChEMBL | Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine | B | 4.17 | pIC50 | 67000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1809-1811 [PMID:11459637] |
Fucosyltransferase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4985] [UniProtKB: Q9Y231] | ||||||||
ChEMBL | Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting | B | 4.11 | pKi | 77900 | nM | Ki | Bioorg Med Chem (2014) 22: 6430-6437 [PMID:25438767] |
ChEMBL | Inhibition of human recombinant alpha1,3-fucosyltransferase 9 using GDP-[14C]-fucose preincubated for 30 mins by liquid scintillation counting | B | 4.23 | pIC50 | 59000 | nM | IC50 | Bioorg Med Chem (2014) 22: 6430-6437 [PMID:25438767] |
P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
ChEMBL | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production | F | 4.35 | pEC50 | 45000 | nM | EC50 | J Med Chem (2006) 49: 5532-5543 [PMID:16942026] |
Ras-related protein Rab-7a in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105784] [UniProtKB: P51149] | ||||||||
ChEMBL | Binding affinity to Rab7 GTPase L129F mutant (unknown origin) assessed as equilibrium dissociation constant | B | 6.96 | pKd | 109.2 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (2014) |
ChEMBL | Binding affinity to Rab7 GTPase V162M mutant (unknown origin) assessed as equilibrium dissociation constant | B | 7.04 | pKd | 92.12 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (2014) |
ChEMBL | Binding affinity to Rab7 GTPase N161T mutant (unknown origin) assessed as equilibrium dissociation constant | B | 7.42 | pKd | 37.62 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (2014) |
ChEMBL | Binding affinity to wild-type Rab7 (unknown origin) assessed as equilibrium dissociation constant | B | 7.59 | pKd | 25.83 | nM | Kd | US-8765803-B1. Rab7 GTPase inhibitors and related methods of treatment (2014) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]