cabergoline [Ligand Id: 37] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201087 (FCE 21336, Dostinex, Cabaser, Cabergoline, FCE-21336)
  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • 8.88
1 CHEMBL1201087_lig_chart_1 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
  • This target only has 1 pki data point
  • 7.7
2 CHEMBL1201087_lig_chart_2 5-HT1A receptor Human
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
  • This target only has 1 pki data point
  • 6.3
3 CHEMBL1201087_lig_chart_3 5-HT1B receptor Human
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
  • This target only has 1 pki data point
  • 8.1
4 CHEMBL1201087_lig_chart_4 5-HT1D receptor Human
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
  • 8.2
5 CHEMBL1201087_lig_chart_5 5-HT2A receptor Human
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
  • 6.2
6 CHEMBL1201087_lig_chart_6 5-HT2C receptor Human
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  • α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
  • This target only has 1 pki data point
  • 6.5
7 CHEMBL1201087_lig_chart_7 α1A-adrenoceptor Human
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  • α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 7.9
8 CHEMBL1201087_lig_chart_8 α2A-adrenoceptor Human
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  • α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 7.1
9 CHEMBL1201087_lig_chart_9 α2B-adrenoceptor Human
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  • α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 7.7
10 CHEMBL1201087_lig_chart_10 α2C-adrenoceptor Human
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  • D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
  • This target only has 1 pki data point
  • 6.7
11 CHEMBL1201087_lig_chart_11 D1 receptor Human
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  • D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
  • This target only has 1 pki data point
  • 9.2
12 CHEMBL1201087_lig_chart_12 D2 receptor Human
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  • D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 9.1
13 CHEMBL1201087_lig_chart_13 D3 receptor Human
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  • D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
  • 7.3
14 CHEMBL1201087_lig_chart_14 D4 receptor Human
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  • D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
  • This target only has 1 pki data point
  • 7.7
15 CHEMBL1201087_lig_chart_15 D5 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis B 8.85 pKi 1.4 nM Ki ACS Med. Chem. Lett. (2013) 4: 254-258 [PMID:23606928]
GtoPdb - - 8.9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 7.7 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 6.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 8.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 8.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 6.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α1A-adrenoceptor in Human [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 6.5 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb - - 7.9 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089]
GtoPdb - - 7.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 7.7 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D1 receptor in Human [GtoPdb: 214] [UniProtKB: P21728]
GtoPdb - - 6.7 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 9.2 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb - - 9.1 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb - - 7.3 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]
D5 receptor in Human [GtoPdb: 218] [UniProtKB: P21918]
GtoPdb - - 7.7 pKi - - - J Pharmacol Exp Ther (2002) 303: 791-804 [PMID:12388666]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]