ChEMBL ligand: CHEMBL401633
NRAS/GTPase NRas in Human [ChEMBL: CHEMBL2079845] [GtoPdb: 2823] [UniProtKB: P01111] There should be some charts here, you may need to enable JavaScript!
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] There should be some charts here, you may need to enable JavaScript!
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NRAS/GTPase NRas in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079845] [GtoPdb: 2823] [UniProtKB: P01111]
ChEMBL	AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.	B	5.75	pIC50	1760	nM	IC50	US-11254667-B2. Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors (2022)
ChEMBL	IC50 Kinase Assays: Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control. The positive control, Staurosporine, was tested in a 10-dose IC50 mode with 4-fold serial dilution starting at 20 uM. Reactions were carried out at 10 uM ATP. Curve fits were performed to determine IC50 where the enzyme activities at the highest concentration of compounds were less than 65%.	B	5.75	pIC50	1760	nM	IC50	US-11542261-B2. Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors (2023)
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL	Inhibition of IRAK1	B	4.64	pIC50	23000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 3656-3660 [PMID:18501603]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 3656-60 [PMID:18501603]
ChEMBL	Inhibition of IRAK4	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 3656-3660 [PMID:18501603]
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL	AlphaLISA Assay: AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.	B	7.52	pIC50	30	nM	IC50	US-11254667-B2. Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors (2022)

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]