Synonyms: ARD2585 | compound 43 [PMID: 34473519]
Compound class:
Synthetic organic
Comment: ARD-2585 is a highly potent and orally bioavailable PROTAC androgen receptor (AR) degrader molecule [1]. It was designed to reduce AR in metastatic castration-resistant prostate cancer (mCRPC), as an alternative mechanism to antagonising AR signaling with drugs such as enzalutamide and apalutamide. Structurally ARD-2585 is a bifunctional molecule that contains an AR antagonist ligand linked to a cereblon binding component, that targets the AR to the cereblon/cullin 4A E3 ligase complex for degradation. It shares structural similarities to bavdegalutamide, which was the first AR PROTAC to advance to clinical evaluation in humans.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
ARD2585 | compound 43 [PMID: 34473519] |
Database Links ![]() |
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GtoPdb PubChem SID | 458923790 |
PubChem CID | 162366967 |
RCSB PDB Ligand | 0QQ |
Search Google for chemical match using the InChIKey | LUCHABJUYSYJAT-RVWRWSNSSA-N |
Search Google for chemicals with the same backbone | LUCHABJUYSYJAT |
UniChem Compound Search for chemical match using the InChIKey | LUCHABJUYSYJAT-RVWRWSNSSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | LUCHABJUYSYJAT-RVWRWSNSSA-N |