compound 46 [PMID: 16451062] | Ligand Activity Charts

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compound 46 [PMID: 16451062]
Ligand Activity Charts

compound 46 [PMID: 16451062] [Ligand Id: 8355] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL201307
aurora kinase A/Aurora kinase A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
aurora kinase B/Aurora kinase B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] There should be some charts here, you may need to enable JavaScript!
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 8/Mitogen-activated protein kinase 8 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase Src in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
K_v11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aurora kinase A/Aurora kinase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
GtoPdb	-	-	9	pIC50	<1	nM	IC50	J Med Chem (2006) 49: 955-70 [PMID:16451062]
ChEMBL	Inhibition of Aurora A kinase activity	B	9	pIC50	<1	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
ChEMBL	Inhibition of aurora A kinase	B	9	pIC50	<1	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of Aurora A kinase	B	9	pIC50	<1	nM	IC50	Nat Chem Biol (2006) 2: 358-364 [PMID:16783341]
aurora kinase B/Aurora kinase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb	-	-	8.15	pIC50	<7	nM	IC50	J Med Chem (2006) 49: 955-70 [PMID:16451062]
ChEMBL	Inhibition of aurora B kinase	B	8.15	pIC50	7	nM	IC50	J Med Chem (2009) 52: 2629-2651 [PMID:19320489]
ChEMBL	Inhibition of Aurora B kinase	B	8.15	pIC50	7	nM	IC50	Nat Chem Biol (2006) 2: 358-364 [PMID:16783341]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibitory activity against CDK2	B	4.21	pIC50	62000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
epidermal growth factor receptor/Epidermal growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibitory activity against EGFR	B	6.1	pIC50	800	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
ChEMBL	Inhibition of EGFR kinase	B	6.1	pIC50	800	nM	IC50	Nat Chem Biol (2006) 2: 358-364 [PMID:16783341]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL	Inhibitory activity against FAK	B	5.4	pIC50	4000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL	Inhibitory activity against IGFR	B	4.89	pIC50	13000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibitory activity against p38-alpha MAPK	B	4	pIC50	>100000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
mitogen-activated protein kinase 8/Mitogen-activated protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL	Inhibitory activity against JNK1alpha	B	4	pIC50	>100000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
SRC proto-oncogene, non-receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase Src in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibitory activity against SRC	B	5.52	pIC50	3000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL	Inhibitory activity against CSK	B	4.68	pIC50	21000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL	Inhibitory activity against JAK3	B	4.6	pIC50	25000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibitory activity against KDR	B	6	pIC50	1000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]
K_v11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibitory activity against human hERG receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 955-970 [PMID:16451062]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]