butyric acid [Ligand Id: 1059] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14227 (Butanoic acid)
  • FFA3 receptor/Free fatty acid receptor 3 in Human [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
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  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
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  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
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  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
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  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
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  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
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  • FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
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  • HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
GtoPdb - - 4.9 pEC50 - - - J. Biol. Chem. (2003) 278: 11312-9 [PMID:12496283];
J. Biol. Chem. (2003) 278: 25481-9 [PMID:12711604];
Proc. Natl. Acad. Sci. U.S.A. (2004) 101: 1045-50 [PMID:14722361];
J. Biol. Chem. (2011) 286: 10628-40 [PMID:21220428]
ChEMBL Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method B 4.92 pEC50 12000 nM EC50 J Med Chem (2018) 61: 47-61 [PMID:28745893]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of human recombinant HDAC1 B 4.8 pIC50 16000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 39-42 [PMID:21874153]
GtoPdb - - 4.8 pIC50 16000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
GtoPdb - - 4.92 pIC50 12000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
ChEMBL Inhibition of human recombinant HDAC2 B 4.92 pIC50 12000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 39-42 [PMID:21874153]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL Inhibition of human recombinant HDAC3 B 5.05 pIC50 9000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 39-42 [PMID:21874153]
GtoPdb - - 5.05 pIC50 9000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
GtoPdb - - 4.82 pIC50 15000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
ChEMBL Inhibition of human recombinant HDAC8 B 4.82 pIC50 15000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 39-42 [PMID:21874153]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.09 pKi 82000 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.09 pKi 81283.05 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
GtoPdb - - 4.6 pEC50 - - - J. Biol. Chem. (2003) 278: 11312-9 [PMID:12496283];
Biochem. Biophys. Res. Commun. (2003) 303: 1047-52 [PMID:12684041];
J. Biol. Chem. (2003) 278: 25481-9 [PMID:12711604];
J. Biol. Chem. (2011) 286: 10628-40 [PMID:21220428]
HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4]
GtoPdb - - 2.8 pEC50 - - -

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]