butyric acid [Ligand Id: 1059] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14227 (Butanoic acid, Butyrate, Butyric acid, Butyricum acidum, FEMA NO. 2221, N-butanoic acid, N-butyric acid, Normal butyric acid, NSC-8415)
  • FFA3 receptor/Free fatty acid receptor 3 in Human [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
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  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
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  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
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  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
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  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
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  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
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  • FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
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  • HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843]
GtoPdb - - 4.9 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]
ChEMBL Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method F 4.92 pEC50 12000 nM EC50 J Med Chem (2018) 61: 47-61 [PMID:28745893]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of human recombinant HDAC1 B 4.8 pIC50 16000 nM IC50 ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153]
GtoPdb - - 4.8 pIC50 16000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
GtoPdb - - 4.92 pIC50 12000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
ChEMBL Inhibition of human recombinant HDAC2 B 4.92 pIC50 12000 nM IC50 ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL Inhibition of human recombinant HDAC3 B 5.05 pIC50 9000 nM IC50 ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153]
GtoPdb - - 5.05 pIC50 9000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
GtoPdb - - 4.82 pIC50 15000 nM IC50 ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153]
ChEMBL Inhibition of human recombinant HDAC8 B 4.82 pIC50 15000 nM IC50 ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.09 pKi 82000 nM Ki J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 4.09 pKi 81283.05 nM Ki J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552]
GtoPdb - - 4.6 pEC50 - - - J Biol Chem (2003) 278: 11312-9 [PMID:12496283];
Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041];
J Biol Chem (2003) 278: 25481-9 [PMID:12711604];
J Biol Chem (2011) 286: 10628-40 [PMID:21220428]
HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4]
GtoPdb - - 2.8 pEC50 - - -

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]