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ChEMBL ligand: CHEMBL14227 (Butanoic acid, Butyrate, Butyric acid, Butyricum acidum, FEMA NO. 2221, N-butanoic acid, N-butyric acid, Normal butyric acid, NSC-8415) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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FFA3 receptor/Free fatty acid receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5201] [GtoPdb: 227] [UniProtKB: O14843] | ||||||||
GtoPdb | - | - | 4.9 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; Proc Natl Acad Sci USA (2004) 101: 1045-50 [PMID:14722361]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
ChEMBL | Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method | F | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (2018) 61: 47-61 [PMID:28745893] |
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
ChEMBL | Inhibition of human recombinant HDAC1 | B | 4.8 | pIC50 | 16000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
GtoPdb | - | - | 4.8 | pIC50 | 16000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
GtoPdb | - | - | 4.92 | pIC50 | 12000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
ChEMBL | Inhibition of human recombinant HDAC2 | B | 4.92 | pIC50 | 12000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
ChEMBL | Inhibition of human recombinant HDAC3 | B | 5.05 | pIC50 | 9000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
GtoPdb | - | - | 5.05 | pIC50 | 9000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
GtoPdb | - | - | 4.82 | pIC50 | 15000 | nM | IC50 | ACS Med Chem Lett (2010) 2: 39-42 [PMID:21874153] |
ChEMBL | Inhibition of human recombinant HDAC8 | B | 4.82 | pIC50 | 15000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] | ||||||||
ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.09 | pKi | 82000 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
ChEMBL | Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr | B | 4.09 | pKi | 81283.05 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
FFA2 receptor in Human [GtoPdb: 226] [UniProtKB: O15552] | ||||||||
GtoPdb | - | - | 4.6 | pEC50 | - | - | - |
J Biol Chem (2003) 278: 11312-9 [PMID:12496283]; Biochem Biophys Res Commun (2003) 303: 1047-52 [PMID:12684041]; J Biol Chem (2003) 278: 25481-9 [PMID:12711604]; J Biol Chem (2011) 286: 10628-40 [PMID:21220428] |
HCA2 receptor in Human [GtoPdb: 312] [UniProtKB: Q8TDS4] | ||||||||
GtoPdb | - | - | 2.8 | pEC50 | - | - | - |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]