diacerein [Ligand Id: 10800] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL41286 (AC-201, Ac-203, Artrodar, Diacerein, Diacereina, Diacereine, Diacerhein, Diacetylrhein, Diora, Fisiodar, M-01AX21, M01AX21, NSC-758147, Rhein diacetate, SF-277, Verboril, Zondar)
  • N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083]
ChEMBL Time dependent inhibition of recombinant human NAAA expressed in HEK293 cells by liquid scintillation counting method B 6.15 pIC50 700 nM IC50 J Med Chem (2017) 60: 4-46 [PMID:27766867]
ChEMBL Time dependent inhibition of recombinant human NAAA expressed in HEK293 cell membranes using [14C]-PEA as substrate by liquid scintillation counting method B 6.15 pIC50 700 nM IC50 J Med Chem (2017) 60: 4-46 [PMID:27766867]
ChEMBL Inhibition of NAAA (unknown origin) B 6.15 pIC50 700 nM IC50 J Med Chem (2020) 63: 7475-7490 [PMID:32191459]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay B 5.27 pIC50 5400 nM IC50 Bioorg Med Chem (2021) 44: 116292-116292 [PMID:34225167]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]