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ChEMBL ligand: CHEMBL41286 (AC-201, Ac-203, Artrodar, Diacerein, Diacerhein, Diacetylrhein, Diora, Fisiodar, M-01AX21, M01AX21, NSC-758147, Rhein diacetate, SF-277, Verboril, Zondar) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083] | ||||||||
ChEMBL | Time dependent inhibition of recombinant human NAAA expressed in HEK293 cells by liquid scintillation counting method | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2017) 60: 4-46 [PMID:27766867] |
ChEMBL | Time dependent inhibition of recombinant human NAAA expressed in HEK293 cell membranes using [14C]-PEA as substrate by liquid scintillation counting method | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2017) 60: 4-46 [PMID:27766867] |
ChEMBL | Inhibition of NAAA (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (2020) 63: 7475-7490 [PMID:32191459] |
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
ChEMBL | Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay | B | 5.27 | pIC50 | 5400 | nM | IC50 | Bioorg Med Chem (2021) 44: 116292-116292 [PMID:34225167] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]