compound 2 [PMID: 21105727] [Ligand Id: 6222] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1630805 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| GtoPdb | - | - | 6 | pKi | 1000 | nM | Ki | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
| ChEMBL | Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay | B | 6 | pKi | 1000 | nM | Ki | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| ChEMBL | Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay | F | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| GtoPdb | - | - | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2888] [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| ChEMBL | Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay | F | 4.87 | pEC50 | 13400 | nM | EC50 | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| GtoPdb | - | - | 4.9 | pEC50 | 13400 | nM | EC50 | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
