ChEMBL ligand: CHEMBL484928 (BRL-50481)
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7A/Phosphodiesterase 7A in Human [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 7B in Human [GtoPdb: 1306] [UniProtKB: Q9NP56] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assay	B	5.74	pIC50	1800	nM	IC50	J Med Chem (2014) 57: 8590-8607 [PMID:25264825]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assay	B	5.89	pIC50	1280	nM	IC50	J Med Chem (2014) 57: 8590-8607 [PMID:25264825]
phosphodiesterase 7A/Phosphodiesterase 7A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3012] [GtoPdb: 1305] [UniProtKB: Q13946]
ChEMBL	Inhibition of human recombinant PDE7A using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assay	B	5.63	pIC50	2320	nM	IC50	Eur J Med Chem (2021) 209: 112854-112854 [PMID:33022582]
ChEMBL	Inhibition of human recombinant PDE7A1 expressed in baculovirus-infected insect Sf9 cells by modified two-step method	B	5.66	pIC50	2200	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2129-2132 [PMID:19303290]
ChEMBL	Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay	B	5.68	pIC50	2100	nM	IC50	Eur J Med Chem (2018) 146: 381-394 [PMID:29407965]
ChEMBL	Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay	B	5.68	pIC50	2100	nM	IC50	Eur J Med Chem (2018) 158: 517-533 [PMID:30245393]
GtoPdb	-	-	6.8	pIC50	-	-	-	Mol Pharmacol (2004) 66: 1679-89 [PMID:15371556]; J Biomol Screen (2010) 15: 359-67 [PMID:20228279]
ChEMBL	Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assay	B	7.05	pIC50	90	nM	IC50	J Med Chem (2012) 55: 3274-3284 [PMID:22385507]
ChEMBL	Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay	B	7.05	pIC50	90	nM	IC50	J Med Chem (2014) 57: 8590-8607 [PMID:25264825]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
phosphodiesterase 7B in Human [GtoPdb: 1306] [UniProtKB: Q9NP56]
GtoPdb	-	-	4.9	pIC50	-	-	-	J Biomol Screen (2010) 15: 359-67 [PMID:20228279]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]