Top ▲

phosphodiesterase 7B

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1306

Nomenclature: phosphodiesterase 7B

Abbreviated Name: PDE7B

Family: Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 6q23.3 PDE7B phosphodiesterase 7B
Mouse - 446 10 A3 Pde7b phosphodiesterase 7B
Rat - - 1p12 Pde7b phosphodiesterase 7B
Previous and Unofficial Names Click here for help
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.1.4.17
Rank order of affinity (Human)
cyclic AMP >> cyclic GMP  [2]

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
dipyridamole Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 5.7 – 6.0 pIC50 2-3
pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [2-3]
SCH51866 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.8 pIC50 3
pIC50 5.8 (IC50 1.58x10-6 M) [3]
BRL50481 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.9 pIC50 1
pIC50 4.9 [1]

References

Show »

1. Alaamery MA, Wyman AR, Ivey FD, Allain C, Demirbas D, Wang L, Ceyhan O, Hoffman CS. (2010) New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen, 15 (4): 359-67. [PMID:20228279]

2. Gardner C, Robas N, Cawkill D, Fidock M. (2000) Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun, 272 (1): 186-92. [PMID:10872825]

3. Sasaki T, Kotera J, Yuasa K, Omori K. (2000) Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun, 271 (3): 575-83. [PMID:10814504]

Contributors

Show »

How to cite this page