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phosphodiesterase 7B

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Target not currently curated in GtoImmuPdb

Target id: 1306

Nomenclature: phosphodiesterase 7B

Abbreviated Name: PDE7B

Family: Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 6q23.3 PDE7B phosphodiesterase 7B
Mouse - 446 10 A3 Pde7b phosphodiesterase 7B
Rat - - 1p12 Pde7b phosphodiesterase 7B
Previous and Unofficial Names Click here for help
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Database Links Click here for help
Alphafold Q9NP56 (Hs), Q9QXQ1 (Mm)
BRENDA 3.1.4.17
CATH/Gene3D 1.10.1300.10
ChEMBL Target CHEMBL4716 (Hs)
DrugBank Target Q9NP56 (Hs)
Ensembl Gene ENSG00000171408 (Hs), ENSMUSG00000019990 (Mm), ENSRNOG00000013436 (Rn)
Entrez Gene 27115 (Hs), 29863 (Mm), 140929 (Rn)
Human Protein Atlas ENSG00000171408 (Hs)
KEGG Enzyme 3.1.4.17
KEGG Gene hsa:27115 (Hs), mmu:29863 (Mm), rno:140929 (Rn)
OMIM 604645 (Hs)
Pharos Q9NP56 (Hs)
UniProtKB Q9NP56 (Hs), Q9QXQ1 (Mm)
Wikipedia PDE7B (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.4.17
Rank order of affinity (Human)
cyclic AMP >> cyclic GMP  [2]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
dipyridamole Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.7 – 6.0 pIC50 2-3
⤷ pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [2-3]
SCH51866 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.8 pIC50 3
⤷ pIC50 5.8 (IC50 1.58x10-6 M) [3]
BRL50481 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.9 pIC50 1
⤷ pIC50 4.9 [1]

References

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1. Alaamery MA, Wyman AR, Ivey FD, Allain C, Demirbas D, Wang L, Ceyhan O, Hoffman CS. (2010) New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen, 15 (4): 359-67. [PMID:20228279]

2. Gardner C, Robas N, Cawkill D, Fidock M. (2000) Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun, 272 (1): 186-92. [PMID:10872825]

3. Sasaki T, Kotera J, Yuasa K, Omori K. (2000) Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun, 271 (3): 575-83. [PMID:10814504]

Contributors

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