Sch.336 [Ligand Id: 9799] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL180465
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
GtoPdb - - 6.04 pKi 905 nM Ki Bioorg Med Chem Lett (2005) 15: 783-6 [PMID:15664857]
ChEMBL Binding affinity for cannabinoid receptor 1 B 6.04 pKi 905 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 783-786 [PMID:15664857]
GtoPdb - - 6.7 pEC50 200 nM EC50 J Pharmacol Exp Ther (2006) 316: 780-8 [PMID:16258021]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
GtoPdb Measuring competitin binding with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes. - 8.74 pKi 1.8 nM Ki J Pharmacol Exp Ther (2006) 316: 780-8 [PMID:16258021]
ChEMBL Inhibition constant against Cannabinoid receptor 2 B 9.4 pKi 0.4 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 4417-4420 [PMID:16115769]
GtoPdb - - 9.4 pKi 0.4 nM Ki Bioorg Med Chem Lett (2005) 15: 783-6 [PMID:15664857]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]