compound 19a [PMID: 30503936]

Ligand id: 10181

Name: compound 19a [PMID: 30503936]

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 133.8
Molecular weight 728.24
XLogP 4.87
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Comments
Compound 19a was designed as a small molecule type II kinase inhibitor to target c-Met in cancers, with improved drug-like properties, and pharmacokinetic and toxicity profiles compared to previously reported inhibitors of c-Met [1]. It is a multi-tyrosine kinase inhibitor with targets including c-Met, Ron (macrophage stimulating 1 receptor), c-Kit, AXL and IGF-1R, and it is reported to be effective against drug-sensitive and drug-resistant cancer cell lines.
Database Links
GtoPdb PubChem SID 381118891
Search Google for chemical match using the InChIKey GZVQZLVAKXRTHU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GZVQZLVAKXRTHU
Search UniChem for chemical match using the InChIKey GZVQZLVAKXRTHU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GZVQZLVAKXRTHU