Compound class:
Synthetic organic
Comment: JH-XI-10-02 is a bivalent molecule described as a PROTAC (proteolysis targeting chimera) that simultaneously inhibits CDK8 kinase activity and recruits E3 ligase CRL4Cereblon to target CDK8 for destruction via E3 ligase-mediated ubiquitination and proteasomal degradation. JH-XI-10-02 contains a pomalidomide domain that is connected to the CDK8 inhibitor via a PEG linker. It is the pomalidomide moiety that binds to the ubiquitously expressed E3 ligase receptor cereblon. The kinase inhibitor portion of the molecule is almost identical to JH-VIII-49.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Database Links ![]() |
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GtoPdb PubChem SID | 363894181 |
PubChem CID | 133081965 |
Search Google for chemical match using the InChIKey | JECHBTRAPARMGI-KMIZWFMDSA-N |
Search Google for chemicals with the same backbone | JECHBTRAPARMGI |
UniChem Compound Search for chemical match using the InChIKey | JECHBTRAPARMGI-KMIZWFMDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JECHBTRAPARMGI-KMIZWFMDSA-N |