mercaptoacrylate inhibitor of calpain 1 [Ligand Id: 8570] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3221938
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  • calpain 1 in Pig [GtoPdb: 2336]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750]
ChEMBL Inhibition of Ca2+-dependent activation of porcine calpain-1 using SucLY-AMC as substrate B 7.7 pIC50 20 nM IC50 MedChemComm (2012) 3: 566-570
ChEMBL Inhibition of Ca2+-dependent activation of porcine calpain-1 using H-K(FAM)-EVYGMMK(DABCYL)-OH as substrate by FRET assay B 8.22 pIC50 6 nM IC50 MedChemComm (2012) 3: 566-570
calpain 1 in Pig [GtoPdb: 2336]
GtoPdb - - 8.22 pIC50 6 nM IC50 Medchemcomm (2012) 3: 566

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]