compound 17f [PMID: 19632837] [Ligand Id: 7031] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL584335
  • coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55]
There should be some charts here, you may need to enable JavaScript!
  • protein arginine methyltransferase 1 /Protein-arginine N-methyltransferase 1 in Human [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873]
There should be some charts here, you may need to enable JavaScript!
  • protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55]
GtoPdb - - 7.15 pIC50 70 nM IC50 Bioorg Med Chem Lett (2009) 19: 5063-6 [PMID:19632837]
ChEMBL Inhibition of human CARM1 assessed as inhibition of histone3 methylation B 10.15 pIC50 0.07 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5063-5066 [PMID:19632837]
protein arginine methyltransferase 1 /Protein-arginine N-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873]
ChEMBL Inhibition of PRMT1 B 4.6 pIC50 >25000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5063-5066 [PMID:19632837]
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678]
ChEMBL Inhibition of PRMT3 B 4.6 pIC50 >25000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5063-5066 [PMID:19632837]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]