solabegron [Ligand Id: 9512] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL208427 (Solabegron, Gw427353)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
  • 6.4
1 CHEMBL208427_lig_chart_1 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 1 pki data point
  • 5.8
2 CHEMBL208427_lig_chart_2 Beta-2 adrenergic receptor Human
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • This target only has 0 pki data point
  • 0
3 CHEMBL208427_lig_chart_3 Beta-3 adrenergic receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cells B 6.4 pKi 398.11 nM Ki J. Med. Chem. (2006) 49: 2758-2771 [PMID:16640337]
GtoPdb - - 5.4 pEC50 - - - J Med Chem (2006) 49: 2758-71 [PMID:16640337]
ChEMBL Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production F 5.4 pEC50 3981.07 nM EC50 J. Med. Chem. (2006) 49: 2758-2771 [PMID:16640337]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cells B 5.8 pKi 1584.89 nM Ki J. Med. Chem. (2006) 49: 2758-2771 [PMID:16640337]
ChEMBL Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production F 5.9 pEC50 1258.93 nM EC50 J. Med. Chem. (2006) 49: 2758-2771 [PMID:16640337]
GtoPdb - - 5.9 pEC50 - - - J Med Chem (2006) 49: 2758-71 [PMID:16640337]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
GtoPdb - - 8.4 pEC50 - - - J Med Chem (2006) 49: 2758-71 [PMID:16640337]
ChEMBL Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production F 8.4 pEC50 3.98 nM EC50 J. Med. Chem. (2006) 49: 2758-2771 [PMID:16640337]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]