solabegron [Ligand Id: 9512] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL208427 (Gw427353, Solabegron) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cells | B | 6.4 | pKi | 398.11 | nM | Ki | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 5.4 | pEC50 | - | - | - | J Med Chem (2006) 49: 2758-71 [PMID:16640337] |
| ChEMBL | Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 5.4 | pEC50 | 3981.07 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cells | B | 5.8 | pKi | 1584.89 | nM | Ki | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| ChEMBL | Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 5.9 | pEC50 | 1258.93 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | J Med Chem (2006) 49: 2758-71 [PMID:16640337] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production | F | 8.4 | pEC50 | 3.98 | nM | EC50 | J Med Chem (2006) 49: 2758-2771 [PMID:16640337] |
| GtoPdb | - | - | 8.7 | pEC50 | - | - | - |
J Med Chem (2006) 49: 2758-71 [PMID:16640337]; Pharmacol Ther (2016) 159: 66-82 [PMID:26808167]; Naunyn Schmiedebergs Arch Pharmacol (2013) 386: 177-83 [PMID:23263450] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
