ChEMBL ligand: CHEMBL422 (Amylozine, Apo-trifluoperazine, Flurazine, NSC-17474, NSC-46061, RP-7623, Stelazine, Stelazine fte, Trifluoperazine)
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125] There should be some charts here, you may need to enable JavaScript!
Beta-glucuronidase in Rat [ChEMBL: CHEMBL4814] [UniProtKB: P06760] There should be some charts here, you may need to enable JavaScript!
C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352] There should be some charts here, you may need to enable JavaScript!
Calmodulin in Human [ChEMBL: CHEMBL6093] [UniProtKB: P0DP23] Calmodulin in Bovine [ChEMBL: CHEMBL6092] [UniProtKB: P62157] There should be some charts here, you may need to enable JavaScript!
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] There should be some charts here, you may need to enable JavaScript!
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
Emopamil-binding protein-like in Human [ChEMBL: CHEMBL2311238] [UniProtKB: Q9BY08] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Lysozyme C in Rat [ChEMBL: CHEMBL2297] [UniProtKB: P00697] There should be some charts here, you may need to enable JavaScript!
NS3 in Hepatitis C virus [ChEMBL: CHEMBL1293269] [UniProtKB: A3EZJ3] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1697658] [UniProtKB: P33302] There should be some charts here, you may need to enable JavaScript!
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Trypanothione reductase in Trypanosoma cruzi [ChEMBL: CHEMBL5131] [UniProtKB: P28593] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
H1 receptor in Human [GtoPdb: 262] [UniProtKB: P35367] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
ChEMBL	Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Beta-glucuronidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4814] [UniProtKB: P06760]
ChEMBL	Inhibitory effect of compound on the release of Beta-glucuronidase in rat neutrophils stimulated with fMLP/CB	B	5.11	pIC50	7800	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1011-1014 [PMID:15013012]
C-8 sterol isomerase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
ChEMBL	Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	6.3	pKi	500	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Calmodulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6093] [UniProtKB: P0DP23]
ChEMBL	Binding affinity to calmodulin	B	6	pKd	1000	nM	Kd	J Med Chem (2008) 51: 3081-3093 [PMID:18459732]
Calmodulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6092] [UniProtKB: P62157]
ChEMBL	Binding affinity to dansylated bovine testes CaM by fluorescence analysis in presence of calcium2+	B	5.3	pKd	5000	nM	Kd	Eur J Med Chem (2016) 116: 36-45 [PMID:27043269]
ChEMBL	Binding affinity to bovine brain CaM by FTPFACE analysis	B	5.47	pKd	3400	nM	Kd	Eur J Med Chem (2016) 116: 36-45 [PMID:27043269]
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL	Inhibition of DNA-PK in human U1810 cells after 30 mins	B	4	pIC50	100000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5352-5359 [PMID:22835870]
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb	-	-	9.02	pKi	0.96	nM	Ki	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]; Neuropsychopharmacology (1997) 16: 93-110; discussion 111-35 [PMID:9015795]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Compound was tested for its effect on dopamine saturation analysis	B	9.27	pKd	0.53	nM	Kd	J Med Chem (1986) 29: 359-369 [PMID:2869146]
ChEMBL	Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum	B	8.66	pKi	2.2	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]
ChEMBL	Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone	B	7.8	pIC50	16	nM	IC50	J Med Chem (1986) 29: 359-369 [PMID:2869146]
Emopamil-binding protein-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2311238] [UniProtKB: Q9BY08]
ChEMBL	Binding affinity to emopamil binding protein (unknown origin)	B	8.41	pKi	3.9	nM	Ki	Bioorg Med Chem (2013) 21: 215-222 [PMID:23199475]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)	B	5.29	pKi	5100.8	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)	B	5.21	pIC50	6226	nM	IC50	DrugMatrix in vitro pharmacology data
Lysozyme C in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2297] [UniProtKB: P00697]
ChEMBL	Inhibitory effect of compound on the release of lysozyme in rat neutrophils stimulated with fMLP/CB	B	5.05	pIC50	9000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1011-1014 [PMID:15013012]
NS3 in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293269] [UniProtKB: A3EZJ3]
ChEMBL	Inhibitory concentration against hepatitis C virus helicase; range 0.6-0.7	B	6.15	pIC50	700	nM	IC50	J Med Chem (2005) 48: 1-20 [PMID:15633995]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model	B	5.19	pKi	6500	nM	Ki	J Med Chem (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	F	4.96	pIC50	10900	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	F	5.14	pIC50	7200	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	F	5.2	pIC50	6300	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.83	pIC50	1480	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FCB infected in human erythrocytes after 30 mins by FACS analysis	F	5.72	pEC50	1900	nM	EC50	J Med Chem (2018) 61: 8061-8077 [PMID:29771541]
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697658] [UniProtKB: P33302]
ChEMBL	Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay	B	5.85	pIC50	1400	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1516-1527 [PMID:19188399]
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
ChEMBL	Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled method	B	4.35	pIC50	45000	nM	IC50	J Med Chem (2020) 63: 1937-1963 [PMID:32030976]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus	B	6.39	pKi	411	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	7.82	pKi	15	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Trypanothione reductase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5131] [UniProtKB: P28593]
ChEMBL	Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase (linear competitive type)	B	4.64	pKi	23000	nM	Ki	J Med Chem (1998) 41: 148-156 [PMID:9457238]
ChEMBL	Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase	B	4.14	pIC50	72000	nM	IC50	J Med Chem (1998) 41: 148-156 [PMID:9457238]
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3]
ChEMBL	Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assay	B	5.1	pIC50	8000	nM	IC50	J Med Chem (2016) 59: 9321-9336 [PMID:27362876]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	7.9	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb	-	-	6.4	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb	-	-	7.36	pKi	44	nM	Ki	Neuropsychopharmacology (1997) 16: 93-110; discussion 111-35 [PMID:9015795]
H1 receptor in Human [GtoPdb: 262] [UniProtKB: P35367]
GtoPdb	-	-	7.2	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]