olaratumab   Click here for help

GtoPdb Ligand ID: 9172

Synonyms: IMC-3G3 | Lartruvo® | LY3012207
Approved drug
olaratumab is an approved drug (EMA & FDA (2016))
Compound class: Antibody
Comment: Olaratumab is a fully human anti-platelet-derived growth factor receptor α (PDGFRα) monoclonal antibody, developed by Eli Lilly (link to Lilly's olaratumab webpage here), originally developed by ImClone Systems, Inc. [2].
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record. BLAST peptide sequence analysis reveals identical matches with sequences 8 and 16 from patent US8128929, and directly to clone IMC-3G3 [1]. From patent US8128929 it appears that the epitope recognised by olaratumab overlaps the PDGFRα binding sites for PDGF-AA and PDGF-BB.
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Classification Click here for help
Compound class Antibody
Approved drug? Yes (EMA & FDA (2016))
International Nonproprietary Names Click here for help
INN number INN
9308 olaratumab
Synonyms Click here for help
IMC-3G3 | Lartruvo® | LY3012207
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 352
Reactome Drug Reactome logo R-ALL-9674007
Reactome Reaction Reactome logo R-HSA-9674015
Other databases
GtoPdb PubChem SID 315661255
Search PubMed clinical trials olaratumab
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