D-e-MAPP [Ligand Id: 8817] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL429926 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| N-acylsphingosine amidohydrolase 1/Acid ceramidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5463] [GtoPdb: 2491] [UniProtKB: Q13510] | ||||||||
| ChEMBL | Inhibition of aCDase expressed in human HL60 cell extract | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2012) 20: 6162-6170 [PMID:22989912] |
| alkaline ceramidase 2/Alkaline ceramidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331067] [GtoPdb: 2469] [UniProtKB: Q5QJU3] | ||||||||
| ChEMBL | Inhibition of alkaline ceramidase 2 in human HL-60 cells using 3H]C16-ceramide as substrate after 1 hr by liquid scintillation counting analysis | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2013) 21: 874-882 [PMID:23312611] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
